Direct benefit of vaccinating boys along with girls against oncogenic human papillomavirus: bayesian evidence synthesis.
Direct benefit of vaccinating boys along with girls against oncogenic human papillomavirus: bayesian evidence synthesis.
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接种男孩和女孩反对致癌人乳头瘤病毒的直接益处：贝叶斯证据合成。
DOI：
10.1136/bmj.h2016
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发表时间：
2015-05-12
期刊：
影响因子：
--
通讯作者：
Berkhof J
中科院分区：
文献类型：
--
作者：
Bogaards JA;Wallinga J;Brakenhoff RH;Meijer CJ;Berkhof J
目的 评估如果男孩与女孩一起接种致癌性人乳头瘤病毒 (HPV) 疫苗，可减少男性癌症疫苗可预防负担。设计贝叶斯证据综合方法，用于评估 HPV 16 和 18 型疫苗接种对异性恋男性和男男性行为者肛门癌、阴茎癌和口咽癌负担的影响。据认为，女孩接种疫苗可减少疫苗型 HPV 的传播，从而降低所有男性患 HPV 相关癌症的风险，但不会影响男男性行为者患 HPV 相关癌症的额外风险。设置 荷兰的一般人口。干预措施 将 12 岁男孩纳入 HPV 疫苗接种计划。主要结果衡量质量调整生命年（QALY）和疫苗接种所需的数量。结果 在荷兰，接种 HPV 疫苗之前，每千名男性中有 14.9 人（95% 可信区间为 12.2 至 18.1）QALY 因与 HPV 相关的疫苗可预防癌症而丧失。如果女孩的疫苗接种率保持在目前 60% 的水平，这一负担将减少 37%（28% 至 48%）。为了防止男性中出现另外一例癌症，795 名男孩（660 至 987 名）需要接种疫苗；肛门癌、阴茎癌和口咽癌的肿瘤具体数字分别为 2162、3486 和 1975。如果女孩的疫苗接种率增加到 90%，则男性 HPV 相关癌症的负担将减少 66%（53% 至 805）。在这种情况下，1735 名男孩（1240 至 2900）需要接种疫苗，以防止出现更多病例；肛门癌、阴茎癌和口咽癌的肿瘤特异性数字分别为 2593、29107 和 6484。结论 男性将间接受益于女孩的疫苗接种，但仍面临患 HPV 相关癌症的风险。当女孩疫苗接种率较高时，为男孩接种疫苗的增量益处是由预防肛门癌推动的，这强调了 HPV 预防工作对男男性行为者的重要性。
Objective To assess the reduction in the vaccine preventable burden of cancer in men if boys are vaccinated along with girls against oncogenic human papillomavirus (HPV). Design Bayesian evidence synthesis approach used to evaluate the impact of vaccination against HPV types 16 and 18 on the burden of anal, penile, and oropharyngeal carcinomas among heterosexual men and men who have sex with men. The reduced transmission of vaccine-type HPV from vaccination of girls was assumed to lower the risk of HPV associated cancer in all men but not to affect the excess risk of HPV associated cancers among men who have sex with men. Setting General population in the Netherlands. Intervention Inclusion of boys aged 12 into HPV vaccination programmes. Main outcome measures Quality adjusted life years (QALYs) and numbers needed to vaccinate. Results Before HPV vaccination, 14.9 (95% credible interval 12.2 to 18.1) QALYs per thousand men were lost to vaccine preventable cancers associated with HPV in the Netherlands. This burden would be reduced by 37% (28% to 48%) if the vaccine uptake among girls remains at the current level of 60%. To prevent one additional case of cancer among men, 795 boys (660 to 987) would need to be vaccinated; with tumour specific numbers for anal, penile, and oropharyngeal cancer of 2162, 3486, and 1975, respectively. The burden of HPV related cancer in men would be reduced by 66% (53% to 805) if vaccine uptake among girls increases to 90%. In that case, 1735 boys (1240 to 2900) would need to be vaccinated to prevent an additional case; with tumour specific numbers for anal, penile, and oropharyngeal cancer of 2593, 29107, and 6484, respectively. Conclusions Men will benefit indirectly from vaccination of girls but remain at risk of cancers associated with HPV. The incremental benefit of vaccinating boys when vaccine uptake among girls is high is driven by the prevention of anal carcinomas, which underscores the relevance of HPV prevention efforts for men who have sex with men.
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DOI：
10.1086/597755
发表时间：
2009-05-01
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
D'Souza G;Agrawal Y;Halpern J;Bodison S;Gillison ML
通讯作者：
Gillison ML
DOI：
10.1056/nejmoa0909537
发表时间：
2011-02-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Giuliano AR;Palefsky JM;Goldstone S;Moreira ED Jr;Penny ME;Aranda C;Vardas E;Moi H;Jessen H;Hillman R;Chang YH;Ferris D;Rouleau D;Bryan J;Marshall JB;Vuocolo S;Barr E;Radley D;Haupt RM;Guris D
通讯作者：
Guris D
影响因子：
5
作者：
Frisch, M;Smith, E;Johansen, C
通讯作者：
Johansen, C
影响因子：
6.4
作者：
De Vuyst, Hugo;Clifford, Gary M.;Franceschi, Silvia
通讯作者：
Franceschi, Silvia
影响因子：
3.7
作者：
Burger, Emily A.;Sy, Stephen;Kim, Jane J.
通讯作者：
Kim, Jane J.