Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage.
Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage.
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DOI：
10.1016/j.semcdb.2022.01.007
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发表时间：
2022-11
影响因子：
7.3
通讯作者：
McCoy, Rajiv C.
中科院分区：
文献类型：
--
作者：
Brosens, Jan J.;Bennett, Phillip R.;Abrahams, Vikki M.;Ramhorst, Rosanna;Coomarasamy, Arri;Quenby, Siobhan;Lucas, Emma S.;McCoy, Rajiv C.
与大多数哺乳动物相比，人类妊娠是不寻常的，因为它涉及染色体多样性胚胎，子宫粘膜的周期性破坏和再生，以及胎儿和母体细胞在子宫胎盘界面的紧密整合。毫不奇怪，怀孕往往在怀孕早期动摇。这些丢失是否导致临床流产取决于染色体错误的起源和对胎儿发育的影响以及蜕膜化子宫内膜参与胚胎生物传感和选择的能力。在减数分裂期间起源于卵母细胞的非整倍体驱动与年龄相关的流产风险。相反，蜕膜反应受损的子宫内膜周期的频率可能是流产率逐步增加的原因，每次流产与母亲年龄无关。在妊娠早期，其他的生理机制起作用，以确保大多数失败的妊娠在前三个月末建立血管母胎连接之前流产。在这里，我们总结了对导致流产的机制的调查如何导致对妊娠早期人类胚胎母体选择过程的新见解。
Compared to most mammals, human pregnancy is unusual in that it involves chromosomally diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate integration of fetal and maternal cells at the uteroplacental interface. Not surprisingly, pregnancy often falters in early gestation. Whether these losses result in clinical miscarriages depends on the origins and impacts of chromosomal errors on fetal development and the ability of the decidualizing endometrium to engage in embryo biosensing and selection. Aneuploidy originating in oocytes during meiosis drives the age-related risk of miscarriage. By contrast, the frequency of endometrial cycles with an impaired decidual response may account for the stepwise increase in miscarriage rates with each pregnancy loss independently of maternal age. Additional physiological mechanisms operate in early gestation to ensure that most failing pregnancies are lost before vascular maternal-fetal connections are established by the end of the first trimester. Here, we summarise how investigations into the mechanisms that cause miscarriage led to new insights into the processes that govern maternal selection of human embryos in early gestation.
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DOI：
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