Children with epilepsy and anxiety: Subcortical and cortical differences.
Children with epilepsy and anxiety: Subcortical and cortical differences.
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DOI：
10.1111/epi.12832
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发表时间：
2015-02
期刊：
影响因子：
5.6
通讯作者：
Hermann BP
中科院分区：
文献类型：
--
作者：
Jones JE;Jackson DC;Chambers KL;Dabbs K;Hsu DA;Stafstrom CE;Seidenberg M;Hermann BP
使用假设驱动的方法，在一般人群中的焦虑症牵连的皮质下和皮质区域进行了检查，与对照组相比，最近发作的癫痫与焦虑。本研究报告了焦虑症的发生频率，同时检查了与癫痫儿童焦虑相关的家族、临床和人口统计学变量。参与者包括88名8-18岁的癫痫儿童; 25名患有焦虑症的儿童和63名没有焦虑症的癫痫儿童。49名无焦虑症的对照者被包括在内。收集T1体积MRI扫描;使用FreeSurfer图像分析套件计算皮质下体积和皮质厚度。分析集中在调整措施的皮质下体积和皮质厚度。与对照组相比，癫痫焦虑组的左杏仁核体积大于癫痫无焦虑组（p = 0.027）。在海马体中，组间无显著差异。皮质厚度检查显示，癫痫焦虑组显示左内侧眶额（p=0.001）、右外侧眶额（p=0.017）和右额极（p=0.009）变薄。两组在年龄、性别、智商、发病年龄、药物或癫痫持续时间方面没有差异。与癫痫无焦虑组相比，癫痫焦虑组中有更多焦虑症病史的家庭成员（p=0.005）。焦虑是近期发作的癫痫儿童常见的精神并发症，伴有杏仁核体积增大，眶区和前额叶皮质其他区域皮质变薄，这表明大脑区域的结构异常是一般人群中焦虑症患者报告的功能障碍网络的一部分。这些发现在癫痫的早期过程中是明显的，与癫痫发作的慢性化无关，并且可能与焦虑和抑郁障碍的家族史有关。
Using a hypothesis driven approach, subcortical and cortical regions implicated in anxiety disorders in the general population were examined in children with recent-onset epilepsy with versus without anxiety compared to controls. This study reports frequency of anxiety disorders while examining familial, clinical and demographic variables associated with anxiety in children with epilepsy. Participants included 88 children with epilepsy aged 8–18 years; 25 with a current anxiety disorder and 63 children with epilepsy no current anxiety disorder. 49 controls without anxiety disorders were included. T1 volumetric MRI scans were collected; subcortical volumes and cortical thickness were computed using the FreeSurfer image analysis suite. Analyses focused on adjusted measures of subcortical volumes and cortical thickness. Relative to controls, larger left amygdala volumes were found in the Epilepsy Anxiety group compared to the Epilepsy No Anxiety group (p = 0.027). In the hippocampus there were no significant differences between groups. Examination of cortical thickness demonstrated that the Epilepsy Anxiety group showed thinning in left medial orbitofrontal (p=0.001), right lateral orbitofrontal (p=0.017), and right frontal pole (p=0.009). There were no differences between groups in age, sex, IQ, age of onset, medications, or duration of epilepsy. There were more family members with a history of anxiety disorders in the Epilepsy Anxiety group compared to the Epilepsy No Anxiety group (p=0.005). Anxiety is a common psychiatric comorbidity in children with recent-onset epilepsy with volumetric enlargement of the amygdala and thinner cortex in orbital and other regions of prefrontal cortex, suggesting structural abnormalities in brain regions that are part of the dysfunctional networks reported in individuals with anxiety disorders in the general population. These findings are evident early in the course of epilepsy, are not related to chronicity of seizures, and may be linked to a family history of anxiety and depressive disorders.
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影响因子：
10.6
作者：
Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
2.6
作者：
Adewuya, AO;Ola, BA
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Ola, BA
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作者：
Hesdorffer DC;Caplan R;Berg AT
通讯作者：
Berg AT
影响因子：
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作者：
Brewin, Chris R.;Lanius, Ruth A.;Galea, Sandro
通讯作者：
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3
作者：
Alwash, RH;Hussein, MJ;Matloub, FF
通讯作者：
Matloub, FF