Pairwise Interactions among Brain Regions Organize Large-Scale Functional Connectivity during Execution of Various Tasks
Pairwise Interactions among Brain Regions Organize Large-Scale Functional Connectivity during Execution of Various Tasks
复制标题
在执行各种任务期间，大脑区域之间的成对相互作用组织大规模的功能连接
DOI：
10.1016/j.neuroscience.2019.05.011
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发表时间：
2019-08
期刊：
影响因子：
3.3
通讯作者：
Yu Shan
中科院分区：
文献类型：
--
作者：
Niu Weikun;Huang Xuhui;Xu Kaibin;Jiang Tianzi;Yu Shan
空间上分离的大脑区域相互作用，形成具有协调活动的网络，支持各种大脑功能。脑区之间的相互作用结构已经通过成对测量得到了广泛的研究。然而，多个（例如，三重和四重）区域不能简化为成对相互作用。这种高阶相互作用（HOI），例如，异或（XOR）运算在计算系统中被广泛实现，并且对于有效的信息处理是至关重要的。然而，目前尚不清楚当受试者执行特定任务时，大规模脑功能网络中是否存在任何HOI。在这里，我们分析了功能性磁共振成像（fMRI）的数据收集从人类受试者执行各种知觉，运动和认知任务。我们发现，HOI强度的宏观功能网络是非常弱的所有任务，这表明主要的大脑活动不依赖于HOI在宏观层面上的时间尺度为数百毫秒。这些弱HOI在任务中进一步研究了由外部输入激活的神经网络模型，这表明大脑区域之间的弱成对相互作用在不涉及HOI的情况下组织了系统。总之，这些结果表明，在组织不同大脑区域之间的协调活动以支持各种大脑功能方面，成对相互作用占主导地位。
Spatially separated brain areas interact with each other to form networks with coordinated activities, supporting various brain functions. Interaction structures among brain areas have been widely investigated through pairwise measures. However, interactions among multiple (e.g., triple and quadruple) areas cannot be reduced to pairwise interactions. Such higher order interactions (HOIs), e.g., exclusive-or (XOR) operation, are widely implemented in computation systems and are crucial for effective information processing. However, it is currently unclear whether any HOIs are present in large-scale brain functional networks when subjects are executing specific tasks. Here we analyzed functional magnetic resonance imaging (fMRI) data collected from human subjects executing various perceptual, motor, and cognitive tasks. We found that HOI strength in the macroscopic functional networks was very weak for all tasks, suggesting that major brain activities do not rely on HOIs on the macroscopic level at the timescale of hundreds of milliseconds. These weak HOIs during tasks were further investigated with a neural network model activated by external inputs, which suggested that weak pairwise interactions among brain areas organized the system without involving HOIs. Taken together, these results demonstrated the dominance of pairwise interactions in organizing coordinated activities among different brain areas to support various brain functions.
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4.3
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通讯作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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通讯作者：
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