Tumor-targeting bacterial therapy: A potential treatment for oral cancer (Review).

Tumor-targeting bacterial therapy: A potential treatment for oral cancer (Review).
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肿瘤靶向细菌疗法:口腔癌的潜在治疗方法(综述)。

DOI:
10.3892/ol.2014.2525
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发表时间:
2014-12
期刊:
影响因子:
2.9
通讯作者:
Li J
Li J
中科院分区:
医学4区
文献类型:
--
作者:
Liu S;Xu X;Zeng X;Li L;Chen Q;Li J

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某些专性或兼性厌氧细菌,其表现出固有的能力,在体内定殖实体肿瘤,可用于肿瘤靶向。由于基因操纵的细菌可以主动和特异性地渗透到肿瘤组织中,细菌治疗正在成为治疗肿瘤的一种有前途的方法。然而,据我们所知,迄今为止还没有关于口腔癌细菌治疗的报道,口腔癌是世界上最常见的癌症之一。在这篇综述中,在了解肿瘤靶向治疗中使用的细菌策略的进展进行了讨论和特定的细菌菌株,可能有很大的治疗潜力,在口腔鳞状细胞癌(OSCC)的肿瘤靶向治疗的预测,由以前的研究确定。
Certain obligate or facultative anaerobic bacteria, which exhibit an inherent ability to colonize solid tumors in vivo, may be used in tumor targeting. As genetically manipulated bacteria may actively and specifically penetrate into the tumor tissue, bacterial therapy is becoming a promising approach in the treatment of tumors. However, to the best of our knowledge, no reports have been published thus far regarding the bacterial treatment of oral cancer, one of the most common types of cancer worldwide. In this review, the progress in the understanding of bacterial strategies used in tumor-targeted therapy is discussed and particular bacterial strains that may have great therapeutic potential in oral squamous cell carcinoma (OSCC) tumor-targeted therapy are predicted as determined by previous studies.
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