Dietary Polysaccharide from Enteromorpha Clathrata Modulates Gut Microbiota and Promotes the Growth of Akkermansia muciniphila, Bifidobacterium spp. and Lactobacillus spp.
Dietary Polysaccharide from Enteromorpha Clathrata Modulates Gut Microbiota and Promotes the Growth of Akkermansia muciniphila, Bifidobacterium spp. and Lactobacillus spp.
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浒苔膳食多糖可调节肠道微生物群并促进 Akkermansia muciniphila、双歧杆菌属的生长。
DOI：
10.3390/md16050167
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发表时间：
2018-05-17
期刊：
影响因子：
5.4
通讯作者：
Yu G
中科院分区：
文献类型：
--
作者：
Shang Q;Wang Y;Pan L;Niu Q;Li C;Jiang H;Cai C;Hao J;Li G;Yu G
最近，积累的证据表明，肠形clathrata多糖（ECP）可能有助于治疗疾病。然而，作为海洋药物开发的有前途的候选人，尽管经过广泛研究了ECP，但对探索其对肠道菌群的影响的考虑较少。从这个角度来看，鉴于肠道菌群在健康和疾病中的关键作用，我们在这里研究了ECP使用16S rRNA高通量测序对肠道菌群的影响。正如生物信息学分析所揭示的那样，ECP极大地改变了肠道菌群的结构，并显着促进了C57BL/6J小鼠中益生菌的生长。但是，有趣的是，ECP对雄性和雌性微生物群产生了不同的影响。在女性中，ECP增加了双歧杆菌属的丰度。和Akkermansia Muciniphila是下一代益生菌细菌，而在男性中，ECP增加了乳酸杆菌的种群。此外，通过塑造微生物群的更平衡的结构，ECP显着降低了女性肠道的抗原负荷。总的来说，我们的研究首次证明了ECP对肠道菌群的益生元作用，并构成了ECP作为健康促进和疾病管理的新型肠道菌群调节剂的发展。
Recently, accumulating evidence has suggested that Enteromorpha clathrata polysaccharide (ECP) could contribute to the treatment of diseases. However, as a promising candidate for marine drug development, although ECP has been extensively studied, less consideration has been given to exploring its effect on gut microbiota. In this light, given the critical role of gut microbiota in health and disease, we investigated here the effect of ECP on gut microbiota using 16S rRNA high-throughput sequencing. As revealed by bioinformatic analyses, ECP considerably changed the structure of the gut microbiota and significantly promoted the growth of probiotic bacteria in C57BL/6J mice. However, interestingly, ECP exerted different effects on male and female microbiota. In females, ECP increased the abundances of Bifidobacterium spp. and Akkermansia muciniphila, a next-generation probiotic bacterium, whereas in males, ECP increased the population of Lactobacillus spp. Moreover, by shaping a more balanced structure of the microbiota, ECP remarkably reduced the antigen load from the gut in females. Altogether, our study demonstrates for the first time a prebiotic effect of ECP on gut microbiota and forms the basis for the development of ECP as a novel gut microbiota modulator for health promotion and disease management.
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影响因子：
3.2
作者：
Jose PA;Raj D
通讯作者：
Raj D
影响因子：
5.2
作者：
Cani PD;de Vos WM
通讯作者：
de Vos WM
影响因子：
3.4
作者：
Hill JM;Bhattacharjee S;Pogue AI;Lukiw WJ
通讯作者：
Lukiw WJ
影响因子：
2.9
作者：
Bukowczan, Jakub;Cieszkowski, Jakub;Dembinski, Artur
通讯作者：
Dembinski, Artur
DOI：
10.1073/pnas.1219451110
发表时间：
2013-05-28
影响因子：
11.1
作者：
Everard, Amandine;Belzer, Clara;Cani, Patrice D.
通讯作者：
Cani, Patrice D.