Pan-Cancer Analysis of Atrial-Fibrillation-Related Innate Immunity Gene ANXA4.
Pan-Cancer Analysis of Atrial-Fibrillation-Related Innate Immunity Gene ANXA4.
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房颤相关先天免疫基因 ANXA4 的泛癌分析
DOI：
10.3389/fcvm.2021.713983
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发表时间：
2021
影响因子：
3.6
通讯作者：
Guo C
中科院分区：
文献类型：
--
作者：
Yan T;Zhu S;Shi Y;Xie C;Zhu M;Zhang Y;Wang C;Guo C
背景：心房颤动（AF）是世界上最常见的快速性心律失常。癌症是全球主要的死亡原因之一。最近的一项研究表明，癌症与AF的发病率增加。在本研究中，我们的目的是探讨可能的机制和潜在的共同治疗目标之间的AF和癌症。方法：利用蛋白质组学技术，对房颤与窦性心律的差异表达蛋白进行鉴定。应用加权基因相关网络分析将蛋白质聚类到不同模块中，并研究模块与AF之间的关联。通过InnateDB数据库选择Hub免疫相关基因，并使用qRT-PCR进行验证。33种不同癌症类型的RNA测序和临床数据来自癌症基因组图谱（TCGA）。采用考克斯回归分析和Kaplan-Meier生存分析计算ANXA 4表达与预后的相关性。斯皮尔曼等级相关检验用于评估ANXA 4与免疫浸润和DNA甲基化之间的关联。通过基因本体和基因集富集分析（GSEA）进行富集分析。结果：ANXA 4为房颤与窦性心律之间的中枢免疫相关基因。ANXA 4的表达水平在不同的癌症类型中增加。生存分析表明ANXA 4表达水平在各种癌症类型中具有预后意义。免疫相关性分析表明，ANXA 4表达水平与大多数癌症类型中的肿瘤免疫浸润相关。ANXA 4可能通过肿瘤负荷和微卫星不稳定性影响免疫治疗的疗效。GSEA结果表明ANXA 4高表达组主要富集在过氧化物酶体、胆汁酸生物合成和p53途径中。结论：ANXA 4是AF发病的中枢免疫相关基因，目前未见报道。泛癌分析表明，它有潜力作为一种新的临床预后标志物和治疗靶点，在不同的癌症类型。ANXA 4可能在AF和癌症中发挥关键作用，ANXA 4的靶向治疗可能会降低癌症患者AF的发生率。
Background: Atrial fibrillation (AF) is the most common tachyarrhythmia around the world. Cancer is one of the main causes of death worldwide. A recent study demonstrated that cancer was associated with an increased incidence of AF. In the present study, we aimed to explore possible mechanisms and potential common therapeutic targets between AF and cancer. Methods: Differentially expressed proteins between AF and sinus rhythm were identified utilizing proteomics analysis. Weighted gene correlation network analysis was applied to cluster proteins into different modules and investigate associations between modules and AF. Hub immune-related genes were selected via InnateDB database and verified using qRT-PCR. RNA sequencing and clinical data of 33 different cancer types were achieved from The Cancer Genome Atlas (TCGA). The correlations between ANXA4 expression and the prognosis were calculated utilizing Cox regression analysis and Kaplan-Meier survival analysis. Spearman's rank correlation test was used to assess associations between ANXA4 and immune infiltration and DNA methylation. Enrichment analysis was performed through gene ontology and gene set enrichment analysis (GSEA). Results:ANXA4 was identified as hub immune-related gene between AF and sinus rhythm. Expression levels of ANXA4 increased in diverse cancer types. Survival analysis suggested prognostic significance of ANXA4 expression levels in various cancer types. Immune correlation analysis indicated that ANXA4 expression levels were associated with tumor immune infiltration in most cancer types. ANXA4 might influence the efficacy of immunotherapy via tumor burden and microsatellite instability. GSEA results indicated that high ANXA4 expression groups were mainly enriched in peroxisome, bile acid biosynthesis, and p53 pathway. Conclusion:ANXA4 was identified as a hub immune-related gene in AF, which has never been reported. Pan-cancer analysis indicated its potential as a novel clinical prognostic marker and therapeutic target in diverse cancer types. ANXA4 might play crucial roles in AF and cancer, and targeted therapy for ANXA4 might reduce the incidence of AF in cancer patients.
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DOI：
10.1042/bj20081386
发表时间：
2009-01-01
期刊：
The Biochemical journal
影响因子：
--
作者：
Murphy MP
通讯作者：
Murphy MP
影响因子：
37.8
作者：
Huxley RR;Lopez FL;Folsom AR;Agarwal SK;Loehr LR;Soliman EZ;Maclehose R;Konety S;Alonso A
通讯作者：
Alonso A
心耳的蛋白质组学分析揭示心房颤动的病理生理变化
影响因子：
4
作者：
Liu B;Li X;Zhao C;Wang Y;Lv M;Shi X;Han C;Pandey P;Qian C;Guo C;Zhang Y
通讯作者：
Zhang Y
前列腺素E2 EP2受体在肌萎缩性侧面硬化症模型中加速了疾病进展和炎症。
影响因子：
11.2
作者：
Liang, Xibin;Wang, Qian;Shi, Ju;Lokteva, Ludmila;Breyer, Richard M.;Montine, Thomas J.;Andreasson, Katrin
通讯作者：
Andreasson, Katrin
影响因子：
11.2
作者：
Li T;Fan J;Wang B;Traugh N;Chen Q;Liu JS;Li B;Liu XS
通讯作者：
Liu XS