PINCH is an independent prognostic factor in rectal cancer patients without preoperative radiotherapy--a study in a Swedish rectal cancer trial of preoperative radiotherapy.
PINCH is an independent prognostic factor in rectal cancer patients without preoperative radiotherapy--a study in a Swedish rectal cancer trial of preoperative radiotherapy.
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Pinch是直肠癌患者的独立预后因素，没有术前放疗，这是一项术前放射疗法的瑞典直肠癌试验。
DOI：
10.1186/1471-2407-12-65
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发表时间：
2012-02-10
期刊：
影响因子：
3.8
通讯作者：
Sun XF
中科院分区：
文献类型：
--
作者：
Holmqvist A;Gao J;Holmlund B;Adell G;Carstensen J;Langford D;Sun XF
特别有趣的新的富含半胱氨酸-组氨酸的蛋白质（PINCH）表达和肿瘤放射治疗（RT）之间的临床意义尚不清楚。本研究探讨PINCH在直肠癌组织中的表达及其与RT、临床、病理和生物学因素的关系。应用免疫组化方法检测了137例原发性直肠腺癌（72例未行RT，65例行RT）浸润边缘和肿瘤内部PINCH的表达。蛋白质印迹法检测结肠成纤维细胞系（CCD-18 Co）中PINCH的表达。在没有RT的患者中，与弱表达的患者相比，原发肿瘤浸润边缘的强PINCH表达与较差的生存率相关，与TNM分期和分化无关（P = 0.03）。RT患者的生存率无相关性（P = 0.64）。非RT组与RT组比较，PINCH在原发肿瘤中的表达无差异（浸润边缘（P = 0.68）/肿瘤内部区域（P = 0.49））。在RT患者中，强PINCH表达与较高级别的LVD（淋巴管密度）相关（P = 0.01）。在非RT患者中，浸润边缘的PINCH表达是一个独立的预后因素。RT似乎不直接影响PINCH表达。
The clinical significance between particularly interesting new cysteine-histidine rich protein (PINCH) expression and radiotherapy (RT) in tumours is not known. In this study, the expression of PINCH and its relationship to RT, clinical, pathological and biological factors were studied in rectal cancer patients. PINCH expression determined by immunohistochemistry was analysed at the invasive margin and inner tumour area in 137 primary rectal adenocarcinomas (72 cases without RT and 65 cases with RT). PINCH expression in colon fibroblast cell line (CCD-18 Co) was determined by western blot. In patients without RT, strong PINCH expression at the invasive margin of primary tumours was related to worse survival, compared to patients with weak expression, independent of TNM stage and differentiation (P = 0.03). No survival relationship in patients with RT was observed (P = 0.64). Comparing the non-RT with RT subgroup, there was no difference in PINCH expression in primary tumours (invasive margin (P = 0.68)/inner tumour area (P = 0.49). In patients with RT, strong PINCH expression was related to a higher grade of LVD (lymphatic vessel density) (P = 0.01) PINCH expression at the invasive margin was an independent prognostic factor in patients without RT. RT does not seem to directly affect the PINCH expression.
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影响因子：
3.7
作者：
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通讯作者：
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影响因子：
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