Weight loss maintenance following an augmented intervention for early slow weight loss responders: An adaptive trial.
Weight loss maintenance following an augmented intervention for early slow weight loss responders: An adaptive trial.
复制标题
对早期缓慢减肥反应者进行增强干预后维持减肥：一项适应性试验。
DOI：
10.1093/tbm/ibad077
复制
发表时间：
2023
影响因子：
3.6
通讯作者：
Focht,BrianC
中科院分区：
文献类型：
--
作者：
Miller,CarlaK;Nagaraja,HaikadyN;Fujita,Kentaro;Cheavens,JenniferS;Focht,BrianC
治疗期间早期缓慢的体重减轻与总体体重减轻较少相关。在12个月的治疗和6个月的无接触后，评估了为早期缓慢体重减轻反应者设计的增强干预与标准糖尿病预防干预的影响。还确定了标准与增强干预序列对体重和体重的影响。成人≥21岁，超重或肥胖和前驱糖尿病（n= 174）。如果慢反应者在第5周未能实现>2.5%的体重减轻（%WL），则将其分层为增强治疗。在强化干预阶段后的第5个月，根据%WL创建了性别内匹配的参与者对，在扩展干预阶段期间，将对中的每个人随机分配到治疗组，持续5-12个月。两种12个月干预均包括≥7%WL目标。总体而言，平均12个月%WL为5.29%（95% CI：4.27%-6.31%;P< .0001），18个月%WL为3.34%（95% CI：2.01%-4.66%;P< .0001）。标准干预组的%WL（9.55%）大于增强干预组（4.0%）（P= .0001）;早期和缓慢反应者之间的体重恢复无差异（P= .9476）。在控制了第5周的%WL和性别后，标准组和加强组之间12个月时的平均%WL没有差异（P= .23），也没有差异（P> .05）。治疗第一个月后的WL预测12个月和18个月的WL成功，无论干预顺序如何;然而，即使是早期缓慢反应者在治疗期间也实现了显著的WL。需要进一步的研究来支持前驱糖尿病患者有效的WL维持。
Early slow weight loss during treatment is associated with less weight loss overall. The impact of an augmented intervention designed for early slow weight loss responders compared with a standard diabetes prevention intervention was evaluated following 12 months of treatment and 6 months of no contact. The impact of standard vs. augmented intervention sequences on weight and glycemia also was determined. Adults were ≥21 years old with overweight or obesity and prediabetes (n= 174). Slow responders were stratified to augmented treatment if they failed to achieve >2.5% weight loss (%WL) at Week 5. Matched within-sex pairs of participants were created based on %WL at Month 5 following the intensive intervention phase, and each person within the pair was randomly assigned to treatment for Months 5–12 during the extended intervention phase. Both 12-month interventions included a ≥7%WL goal. Mean 12-month %WL was 5.29% (95% CI: 4.27%–6.31%;P< .0001) and 18-month %WL was 3.34% (95% CI: 2.01%–4.66%;P< .0001) overall. %WL was greater for the standard (9.55%) than the augmented (4.0%) intervention (P= .0001); no differences occurred in weight regain between early and slow responders (P= .9476). No differences occurred in mean %WL at 12 months between the standard and augmented groups after controlling for %WL at Week 5 and sex (P= .23) nor in the change in glycemia (allP> .05). WL following the first month of treatment predicted 12- and 18-month WL success regardless of intervention sequence; however, even early slow responders achieved significant WL during treatment. Further research is needed to support effective WL maintenance for people with prediabetes.
登录
查看更多内容
影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
8.8
作者：
Weerasekara, Yasoma Kumari;Roberts, Susan B.;Das, Sai Krupa
通讯作者：
Das, Sai Krupa
BestFIT 序贯多重分配随机试验结果：开发个体化减肥治疗序列的明智方法。
DOI：
10.1093/abm/kaab061
发表时间：
2022
期刊：
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
影响因子：
--
作者：
Sherwood,NancyE;Crain,ALauren;Seburg,ElisabethM;Butryn,MeghanL;Forman,EvanM;Crane,MelissaM;Levy,RonaL;Kunin-Batson,AliciaS;Jeffery,RobertW
通讯作者：
Jeffery,RobertW
新型糖尿病预防干预措施对糖尿病前期成人早期缓慢减肥反应者的影响：一项适应性试验。
影响因子：
16.2
作者：
Miller,CarlaK;Nagaraja,HaikadyN;Cheavens,Jennifer;Fujita,Kentaro;Lazarus,Sophie
通讯作者：
Lazarus,Sophie
影响因子：
9.7
作者：
Ali, Mohammed K.;Echouffo-Tcheugui, Justin B.;Williamson, David F.
通讯作者：
Williamson, David F.