Involvement of TGF-β and Autophagy Pathways in Pathogenesis of Diabetes: A Comprehensive Review on Biological and Pharmacological Insights.
Involvement of TGF-β and Autophagy Pathways in Pathogenesis of Diabetes: A Comprehensive Review on Biological and Pharmacological Insights.
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DOI：
10.3389/fphar.2020.498758
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发表时间：
2020
影响因子：
5.6
通讯作者：
Echeverría J
中科院分区：
文献类型：
--
作者：
Heydarpour F;Sajadimajd S;Mirzarazi E;Haratipour P;Joshi T;Farzaei MH;Khan H;Echeverría J
尽管最近在临床药物方面取得了进展，但糖尿病的治疗仍然需要进一步的进展。因此，正在进行的研究试图确定这种疾病的确切分子机制。具体地说，证据支持几个信号通路在糖尿病的发展中起着关键作用。然而，糖尿病的确切分子机制仍有待探索。这项研究考察了自噬和转化生长因子-β信号通路在糖尿病发病机制和新治疗策略设计中严格参与的令人兴奋的新特征。高血糖、氧化应激和炎症引起的胰腺β细胞自噬异常与糖尿病相关，并伴有胰岛素靶组织自噬异常和糖尿病并发症的进展。因此，脂联素、依折麦布、GABA茶、京尼平苷、利拉鲁肽、番石榴提取物和维生素D等几种治疗药物被证明通过调节自噬途径来抑制糖尿病及其并发症。另一种途径，转化生长因子-β信号通路，似乎在1型和2型糖尿病及其并发症的糖尿病进展、胰岛素抵抗和自身免疫中发挥作用。随后，针对转化生长因子-β信号转导的药物，特别是天然衍生药物，如白藜芦醇、葛根素、姜黄素、橙皮苷和水飞蓟素，以及蜂胶、石蒜和苦瓜提取物，可能成为治疗糖尿病的现有药物的有前途的替代品。这篇综述为糖尿病的医疗保健提供了新的治疗策略的敏锐见解。
Despite recent advancements in clinical drugs, diabetes treatment still needs further progress. As such, ongoing research has attempted to determine the precise molecular mechanisms of the disorder. Specifically, evidence supports that several signaling pathways play pivotal roles in the development of diabetes. However, the exact molecular mechanisms of diabetes still need to be explored. This study examines exciting new hallmarks for the strict involvement of autophagy and TGF-β signaling pathways in the pathogenesis of diabetes and the design of novel therapeutic strategies. Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated with diabetes and accompanied by dysregulated autophagy in insulin target tissues and the progression of diabetic complications. Consequently, several therapeutic agents such as adiponectin, ezetimibe, GABA tea, geniposide, liraglutide, guava extract, and vitamin D were shown to inhibit diabetes and its complications through modulation of the autophagy pathway. Another pathway, TGF-β signaling pathway, appears to play a part in the progression of diabetes, insulin resistance, and autoimmunity in both type 1 and 2 diabetes and complications in diabetes. Subsequently, drugs that target TGF-β signaling, especially naturally derived ones such as resveratrol, puerarin, curcumin, hesperidin, and silymarin, as well as Propolis, Lycopus lucidus, and Momordica charantia extracts, may become promising alternatives to current drugs in diabetes treatment. This review provides keen insights into novel therapeutic strategies for the medical care of diabetes.
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影响因子：
3.5
作者：
Ahlstrom, Penny;Rai, Esther;Sweeney, Gary
通讯作者：
Sweeney, Gary
影响因子：
5.1
作者：
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通讯作者：
Malanda, B.
影响因子：
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作者：
Bartolome, Alberto;Guillen, Carlos;Benito, Manuel
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影响因子：
11.2
作者：
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通讯作者：
Hayward, Simon W.
影响因子：
56.9
作者：
Altmann, SW;Davis, HR;Graziano, MP
通讯作者：
Graziano, MP