Calcium Channels: Noteworthy Regulators and Therapeutic Targets in Dermatological Diseases.
Calcium Channels: Noteworthy Regulators and Therapeutic Targets in Dermatological Diseases.
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钙通道：皮肤疾病中值得注意的调节因子和治疗靶点。
DOI：
10.3389/fphar.2021.702264
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发表时间：
2021
影响因子：
5.6
通讯作者：
Shi H
中科院分区：
文献类型：
--
作者：
Wang M;Sun Y;Li L;Wu P;Dkw O;Shi H
皮肤屏障功能障碍和皮肤内环境稳态受损可导致或加重一系列皮肤病。在皮肤创伤愈合和功能恢复过程中，涉及多种生物学事件和生物活性分子。从细胞内储存释放的钙离子（Ca2+）以及通过质膜流入对皮肤功能是必不可少的。越来越多的证据表明，钙内流主要受钙敏感受体和通道的调节，包括电压门控、瞬时电位受体、钙库操纵和受体操纵的钙通道，它们不仅维持细胞内钙稳态，还通过钙调蛋白（CaM）等钙敏感蛋白参与细胞增殖和皮肤细胞内钙稳态的调节。此外，不同类型的Ca2+通道不仅单独工作，它们还可以协同工作以调节细胞功能。本文综述了电压门控、瞬时受体电位、钙库操纵和受体操纵的钙离子通道，重点介绍了钙离子通道的调节功能、内在相互作用以及钙离子通道相关试剂和药物，以期为皮肤病的基础研究和临床应用提供参考。
Dysfunctional skin barrier and impaired skin homeostasis may lead to or aggravate a series of dermatologic diseases. A large variety of biological events and bioactive molecules are involved in the process of skin wound healing and functional recovery. Calcium ions (Ca2+) released from intracellular stores as well as influx through plasma membrane are essential to skin function. Growing evidence suggests that calcium influx is mainly regulated by calcium-sensing receptors and channels, including voltage-gated, transient potential receptor, store-operated, and receptor-operated calcium channels, which not only maintain cellular Ca2+ homeostasis, but also participate in cell proliferation and skin cell homeostasis through Ca2+-sensitive proteins such as calmodulin (CaM). Furthermore, distinct types of Ca2+ channels not merely work separately, they may work concertedly to regulate cell function. In this review, we discussed different calcium-sensing receptors and channels, including voltage-gated, transient receptor potential, store-operated, and receptor-operated calcium channels, particularly focusing on their regulatory functions and inherent interactions as well as calcium channels-related reagents and drugs, which is expected to bridge basic research and clinical applications in dermatologic diseases.
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影响因子：
5
作者：
Adapala RK;Thoppil RJ;Luther DJ;Paruchuri S;Meszaros JG;Chilian WM;Thodeti CK
通讯作者：
Thodeti CK
影响因子：
64.8
作者：
CARBONE, E;LUX, HD
通讯作者：
LUX, HD
影响因子：
4
作者：
Breitwieser, GE;Miedlich, SU;Zhang, ML
通讯作者：
Zhang, ML
影响因子：
4.8
作者：
Chung, MK;Lee, H;Caterina, MJ
通讯作者：
Caterina, MJ
影响因子：
5
作者：
Caterina, Michael J.
通讯作者：
Caterina, Michael J.