Different compartments of apical CA1 dendrites have different plasticity thresholds for expressing synaptic tagging and capture.

Different compartments of apical CA1 dendrites have different plasticity thresholds for expressing synaptic tagging and capture.
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顶端 CA1 树突的不同区室具有不同的表达突触标记和捕获的可塑性阈值

DOI:
10.1101/lm.2095811
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发表时间:
2011
期刊:
影响因子:
2
通讯作者:
Sajikumar
Sajikumar
中科院分区:
医学4区
文献类型:
--
作者:
Sajikumar

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从短期记忆到长期记忆的巩固过程取决于从特定神经元网络接收的刺激类型,以及汇聚到特定神经元上的不同突触输入之间的协同性和关联性。我们在这里表明,诱导LTP的可塑性阈值是不同的近端和远端室的顶端树突。此外,我们显示了近端和远端舱室的顶端树突之间的相互作用,提供的证据表明,即使是阈下刺激可以激活可塑性相关的蛋白质,如PKM β,使两个不同的树突舱室之间的关联性在顶端树突发生。
The consolidation process from short- to long-term memory depends on the type of stimulation received from a specific neuronal network and on the cooperativity and associativity between different synaptic inputs converging onto a specific neuron. We show here that the plasticity thresholds for inducing LTP are different in proximal and distal compartments of apical dendrites. In addition, we show interactions between the proximal and distal compartments of the apical dendrites by providing evidence that even a subthreshold stimulus can activate plasticity-related proteins, such as PKMζ, enabling associativity between two distinct dendritic compartments in apical dendrites to occur.
DOI: 10.1073/pnas.1016849108
发表时间: 2011-02-08
影响因子: 11.1
作者:
Sajikumar, Sreedharan;Korte, Martin
通讯作者: Korte, Martin
DOI: 10.1002/hipo.1993.4500030707
发表时间: 1993
期刊: Hippocampus
影响因子: 3.5
作者:
M. Witter
通讯作者: M. Witter
IV型特异性磷酸二酯酶抑制剂咯利普兰促丝裂原激活蛋白激酶介导的海马早期长期抑制的强化及其对突触标记的影响
DOI: --
发表时间: 2005
影响因子: 5.3
作者:
Sheeja Navakkode;Sreedharan Sajikumar;J. Frey
通讯作者: J. Frey