Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease.
Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease.
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DOI：
10.1083/jcb.200808137
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发表时间：
2008-11-03
期刊：
影响因子：
--
通讯作者：
Pazour GJ
中科院分区：
文献类型：
--
作者：
Jonassen JA;San Agustin J;Follit JA;Pazour GJ
Primary cilia project from the surface of most vertebrate cells and are thought to be sensory organelles. Defects in primary cilia lead to cystic kidney disease, although the ciliary mechanisms that promote and maintain normal renal function remain incompletely understood. In this work, we generated a floxed allele of the ciliary assembly gene Ift20. Deleting this gene specifically in kidney collecting duct cells prevents cilia formation and promotes rapid postnatal cystic expansion of the kidney. Dividing collecting duct cells in early stages of cyst formation fail to properly orient their mitotic spindles along the tubule, whereas nondividing cells improperly position their centrosomes. At later stages, cells lacking cilia have increased canonical Wnt signaling and increased rates of proliferation. Thus, IFT20 functions to couple extracellular events to cell proliferation and differentiation.
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DOI：
10.1007/s00467-007-0504-4
发表时间：
2007-11
期刊：
Pediatric nephrology (Berlin, Germany)
影响因子：
--
作者：
Merkel CE;Karner CM;Carroll TJ
通讯作者：
Carroll TJ
DOI：
10.1073/pnas.94.26.14602
发表时间：
1997-12-23
影响因子：
11.1
作者：
O'Gorman, S;Dagenais, NA;Marchuk, Y
通讯作者：
Marchuk, Y
影响因子：
3.5
作者：
Patel, Vishal;Li, Ling;Igarashi, Peter
通讯作者：
Igarashi, Peter
影响因子：
7.8
作者：
Koetttgen, Michael;Buchholz, Bjoern;Garcia-Gonzalez, Miguel A.;Kotsis, Fruzsina;Fu, Xiao;Doerken, Mara;Boehlke, Christopher;Steffl, Daniel;Tauber, Robert;Wegierski, Tomasz;Nitschke, Roland;Suzuki, Makoto;Kramer-Zucker, Albrecht;Germino, Gregory G.;Watnick, Terry;Prenen, Jean;Nilius, Bernd;Kuehn, E. Wolfgang;Walz, Gerd
通讯作者：
Walz, Gerd
影响因子：
4
作者：
Chuang, Ya-Yu;Valster, Aline;Symons, Marc
通讯作者：
Symons, Marc