Molecular regulation of kidney development: is the answer blowing in the Wnt?

Molecular regulation of kidney development: is the answer blowing in the Wnt?
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DOI:
10.1007/s00467-007-0504-4
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发表时间:
2007-11
期刊:
Pediatric nephrology (Berlin, Germany)
影响因子:
--
通讯作者:
Carroll TJ
Carroll TJ
中科院分区:
其他
文献类型:
--
作者:
Merkel CE;Karner CM;Carroll TJ

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后肾的发育是一个复杂的过程,由输尿管芽和后肾间充质的相互信号调节,调节小管形成和上皮分支形态发生。在过去的几年里,一些研究表明,Wnt信号转导参与了正常肾脏发育以及损伤反应和癌症进展的多个方面。我们将在这里回顾这些数据。
Development of the metanephric kidney is a complicated process regulated by reciprocal signals from the ureteric bud and the metanephric mesenchyme that regulate tubule formation and epithelial branching morphogenesis. Over the past several years, several studies have suggested that Wnt signaling is involved in multiple aspects of normal kidney development as well as injury response and cancer progression. We will review these data here.
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