A Western diet ecological module identified from the 'humanized' mouse microbiota predicts diet in adults and formula feeding in children.
A Western diet ecological module identified from the 'humanized' mouse microbiota predicts diet in adults and formula feeding in children.
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DOI：
10.1371/journal.pone.0083689
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Parkinson SJ
中科院分区：
文献类型：
--
作者：
Siddharth J;Holway N;Parkinson SJ
饮食和微生物群之间的相互作用与西方生活方式相关的慢性疾病的频率越来越高有关。然而，人类和临床前模型中微生物生态学的复杂性和可变性阻碍了在这种情况下识别微生物群相关的分子机制。我们试图解决两个关键问题。临床前模型的微生物生态学能预测人类种群吗？我们能否确定超越人类微生物生态可塑性的基本原则？为了做到这一点，我们将研究重点放在饮食上;这可能是决定肠道微生物群组成的最有影响力的因素。从“人源化”小鼠的研究开始，我们确定了与西方饮食摄入相关的9个属的相互作用模块。该模块应用于人类的对照饮食研究。西方生态模块的丰度分别正确预测了19/21的顶部和21/21的底部四分位数样本的饮食摄入量，包括所有5个西方和“低脂”饮食受试者。在98名志愿者中，西方模块的丰富程度与饱和脂肪酸、脂溶性维生素和纤维的饮食摄入量相关。此外，它还与西方、发展中国家和第三世界健康成年人的地理位置和饮食习惯有关。该模块还与儿童（和仔猪）的饮食摄入量相关联，与配方奶粉（与母乳）喂养相关联，并与幼儿生态模块的急剧发展相关联。我们的研究提供了一个概念平台，将微生物生态学从临床前模型转化为人类，并确定了肠道微生物群与西方饮食习惯相关的生态网络模块。
The interplay between diet and the microbiota has been implicated in the growing frequency of chronic diseases associated with the Western lifestyle. However, the complexity and variability of microbial ecology in humans and preclinical models has hampered identification of the molecular mechanisms underlying the association of the microbiota in this context. We sought to address two key questions. Can the microbial ecology of preclinical models predict human populations? And can we identify underlying principles that surpass the plasticity of microbial ecology in humans? To do this, we focused our study on diet; perhaps the most influential factor determining the composition of the gut microbiota. Beginning with a study in ‘humanized’ mice we identified an interactive module of 9 genera allied with Western diet intake. This module was applied to a controlled dietary study in humans. The abundance of the Western ecological module correctly predicted the dietary intake of 19/21 top and 21/21 of the bottom quartile samples inclusive of all 5 Western and ‘low-fat’ diet subjects, respectively. In 98 volunteers the abundance of the Western module correlated appropriately with dietary intake of saturated fatty acids, fat-soluble vitamins and fiber. Furthermore, it correlated with the geographical location and dietary habits of healthy adults from the Western, developing and third world. The module was also coupled to dietary intake in children (and piglets) correlating with formula (vs breast) feeding and associated with a precipitous development of the ecological module in young children. Our study provides a conceptual platform to translate microbial ecology from preclinical models to humans and identifies an ecological network module underlying the association of the gut microbiota with Western dietary habits.
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影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
DOI：
10.1007/978-1-4020-9173-5_2
发表时间：
2009-01-01
期刊：
EARLY NUTRITION PROGRAMMING AND HEALTH OUTCOMES IN LATER LIFE: OBESITY AND BEYOND
影响因子：
--
作者：
Koletzko, Berthold;von Kries, Ruediger;Grote, Veit
通讯作者：
Grote, Veit
影响因子：
4.4
作者：
Schloss, Patrick D.;Westcott, Sarah L.;Weber, Carolyn F.
通讯作者：
Weber, Carolyn F.
DOI：
10.1126/science.1208344
发表时间：
2011-10-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Wu GD;Chen J;Hoffmann C;Bittinger K;Chen YY;Keilbaugh SA;Bewtra M;Knights D;Walters WA;Knight R;Sinha R;Gilroy E;Gupta K;Baldassano R;Nessel L;Li H;Bushman FD;Lewis JD
通讯作者：
Lewis JD
影响因子：
4.4
作者：
Schloss, Patrick D.;Westcott, Sarah L.
通讯作者：
Westcott, Sarah L.