N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover.
N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover.
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DOI：
10.1002/dvg.20628
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发表时间：
2010-06
期刊：
影响因子：
1.5
通讯作者：
Semb, Henrik
中科院分区：
文献类型：
--
作者：
Johansson, Jenny K.;Voss, Ulrikke;Kesavan, Gokul;Kostetskii, Igor;Wierup, Nils;Radice, Glenn L.;Semb, Henrik
关键词：
The cadherin family of cell adhesion molecules mediates adhesive interactions that are required for the formation and maintenance of tissues. Previously, we demonstrated that N-cadherin, which is required for numerous morphogenetic processes, is expressed in the pancreatic epithelium at E9.5, but later becomes restricted to endocrine aggregates in mice. To study the role of N-cadherin during pancreas formation and function we generated a tissue specific knockout of N-cadherin in the early pancreatic epithelium by inter-crossing N-cadherin-floxed mice with Pdx1Cre mice. Analysis of pancreas-specific ablation of N-cadherin demonstrates that N-cadherin is dispensable for pancreatic development, but required for β-cell granule turnover. The number of insulin secretory granules is significantly reduced in N-cadherin-deficient β-cells, and as a consequence insulin secretion is decreased.
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影响因子：
2.5
作者：
Luo, Y;Kostetskii, I;Radice, GL
通讯作者：
Radice, GL
DOI：
10.1083/jcb.144.2.325
发表时间：
1999-01-25
期刊：
The Journal of cell biology
影响因子：
--
作者：
Esni F;Täljedal IB;Perl AK;Cremer H;Christofori G;Semb H
通讯作者：
Semb H
影响因子：
3.7
作者：
Tillet, E;Vittet, D;Huber, P
通讯作者：
Huber, P
影响因子：
19.6
作者：
NOUWEN, EJ;DAUWE, S;DEBROE, ME
通讯作者：
DEBROE, ME
N-钙粘蛋白在 VE-钙粘蛋白的上游发挥作用，控制血管形态发生。
影响因子：
7.8
作者：
Luo, Y;Radice, GL
通讯作者：
Radice, GL