N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis.
N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis.
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N-钙粘蛋白在 VE-钙粘蛋白的上游发挥作用，控制血管形态发生。
DOI：
10.1083/jcb.200411127
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发表时间：
2005-04-11
影响因子：
7.8
通讯作者：
Radice, GL
中科院分区：
文献类型：
--
作者：
Luo, Y;Radice, GL
Endothelial cells express two classic cadherins, VE-cadherin and N-cadherin. The importance of VE-cadherin in vascular development is well known; however, the function of N-cadherin in endothelial cells remains poorly understood. Contrary to previous studies, we found that N-cadherin localizes to endothelial cell–cell junctions in addition to its well-known diffusive membrane expression. To investigate the role of N-cadherin in vascular development, N-cadherin was specifically deleted from endothelial cells in mice. Loss of N-cadherin in endothelial cells results in embryonic lethality at mid-gestation due to severe vascular defects. Intriguingly, loss of N-cadherin caused a significant decrease in VE-cadherin and its cytoplasmic binding partner, p120ctn. The down-regulation of both VE-cadherin and p120ctn was confirmed in cultured endothelial cells using small interfering RNA to knockdown N-cadherin. We also show that N-cadherin is important for endothelial cell proliferation and motility. These findings provide a novel paradigm by which N-cadherin regulates angiogenesis, in part, by controlling VE-cadherin expression at the cell membrane.
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影响因子：
64.8
作者：
Yancopoulos, GD;Davis, S;Holash, J
通讯作者：
Holash, J
DOI：
10.1083/jcb.140.6.1475
发表时间：
1998-03-23
期刊：
The Journal of cell biology
影响因子：
--
作者：
Navarro P;Ruco L;Dejana E
通讯作者：
Dejana E
影响因子：
2.7
作者：
Kisanuki, YY;Hammer, RE;Yanagisawa, M
通讯作者：
Yanagisawa, M
影响因子：
4
作者：
Luo, Y;Radice, GL
通讯作者：
Radice, GL
DOI：
10.1083/jcb.200306001
发表时间：
2003-11-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Xiao K;Allison DF;Buckley KM;Kottke MD;Vincent PA;Faundez V;Kowalczyk AP
通讯作者：
Kowalczyk AP