Endocannabinoid system in psychotic and mood disorders, a review of human studies.
Endocannabinoid system in psychotic and mood disorders, a review of human studies.
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DOI：
10.1016/j.pnpbp.2020.110096
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发表时间：
2021-03-02
影响因子：
5.6
通讯作者：
Mizrahi R
中科院分区：
文献类型：
--
作者：
Garani R;Watts JJ;Mizrahi R
尽管有广泛的证据表明内源性大麻素系统参与精神疾病的病理生理学，但我们的理解仍然很初级。在这里，我们回顾了对患有精神病和情绪障碍的人类内源性大麻素系统的研究。尸检、外周血、脑脊液和体内成像研究为内源性大麻素系统在精神病和情绪障碍中的作用提供了证据。精神障碍和重度抑郁症表现出大脑大麻素 CB1 受体和外周血内源性大麻素的改变。此外，这些变化可能对治疗状态、疾病状态和症状严重程度敏感。来自精神障碍的证据延伸到大脑和外周的内源性大麻素代谢酶，而这些证据在情绪障碍中仍然不发达。缺乏对双相情感障碍中这一系统的研究表明文献中存在显着的空白。尽管这一研究领域的富有成果的工作不断增多，但显然需要对 CB1 受体之外的研究进行研究，以便更全面地阐明内源性大麻素系统在精神病和情绪障碍中的作用。
Despite widespread evidence of endocannabinoid system involvement in the pathophysiology of psychiatric disorders, our understanding remains rudimentary. Here we review studies of the endocannabinoid system in humans with psychotic and mood disorders. Postmortem, peripheral, cerebrospinal fluid and in vivo imaging studies provide evidence for the role of the endocannabinoid system in both psychotic and mood disorders. Psychotic disorders and major depressive disorder exhibit alterations of brain cannabinoid CB1 receptors and peripheral blood endocannabinoids. Further, these changes may be sensitive to treatment status, disease state, and symptom severity. Evidence from psychotic disorder extend to endocannabinoid metabolizing enzymes in the brain and periphery, whereas these lines of evidence remain poorly developed in mood disorders. A lack of studies examining this system in bipolar disorder represents a notable gap in the literature. Despite a growing body of productive work in this field of research, there is a clear need for investigation beyond the CB1 receptor in order to more fully elucidate the role of the endocannabinoid system in psychotic and mood disorders.
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