Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level

Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level
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精神分裂症年龄、抗精神病药物和症状严重程度与质子磁共振波谱脑谷氨酸水平的关系

DOI:
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发表时间:
2021
期刊:
影响因子:
25.8
通讯作者:
H. Yamasue
H. Yamasue
中科院分区:
医学1区
文献类型:
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作者:
K. Merritt;P. McGuire;A. Egerton;A. Aleman;W. Block;O. Bloemen;F. Borgan;J. Bustillo;A. Capizzano;Jennifer M. Coughlin;C. de la Fuente;A. Demjaha;K. Dempster;K. Do;F. Du;P. Falkai;B. Galińska;J. Gallinat;C. Gasparovic;Cedric E. Ginestet;Naoki Goto;A. Graff;B. Ho;O. Howes;S. Jauhar;P. Jeon;Tadafumi Kato;C. Kaufmann;L. Kegeles;M. Keshavan;Sang‐Young Kim;H. Kunugi;J. Lauriello;E. Liemburg;Meghan E. Mcilwain;G. Modinos;E. Mouchlianitis;J. Nakamura;I. Nenadić;D. Öngür;M. Ota;L. Palaniyappan;C. Pantelis;E. Plitman;S. Posporelis;S. Purdon;J. Reichenbach;P. Renshaw;B. Russell;A. Sawa;M. Schaefer;D. Shungu;S. Smesny;J. Stanley;J. Stone;A. Szulc;R. Taylor;Katy Thakkar;J. Théberge;P. Tibbo;T. van Amelsvoort;J. Walecki;P. Williamson;S. Wood;L. Xin;H. Yamasue

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要点 问题 临床和人口统计学因素与精神分裂症患者的脑谷氨酸或谷氨酸加谷氨酰胺 (Glx) 水平相关吗?研究结果 在这项对 1251 名精神分裂症患者和 1197 名健康志愿者的大型分析中,患者内侧额叶皮层谷氨酸代谢物水平较低,并且与抗精神病药物剂量呈负相关,尽管与健康个体相比,精神分裂症患者谷氨酸水平随年龄的下降并没有加速。精神分裂症患者的内侧额叶皮层和内侧颞叶谷氨酸水平较高与更严重的症状相关。意味着较低的大脑谷氨酸水平可能与抗精神病药物暴露有关,而不是与年龄相关的衰退更大,而较高的谷氨酸水平可能作为精神分裂症患者疾病严重程度的生物标志物。
Key Points Question Are clinical and demographic factors associated with brain glutamate or glutamate plus glutamine (Glx) levels in schizophrenia? Findings In this mega-analysis of 1251 patients with schizophrenia and 1197 healthy volunteers, medial frontal cortex glutamatergic metabolite levels were lower in patients and negatively associated with the dose of antipsychotic medication, although a reduction in glutamate levels with age was not accelerated in patients with schizophrenia compared with healthy individuals. Higher medial frontal cortex and medial temporal lobe glutamate levels were associated with more severe symptoms in patients with schizophrenia. Meaning Lower brain glutamate levels may be associated with antipsychotic exposure rather than with greater age-related decline, whereas higher glutamate levels may serve as a biomarker of illness severity in patients with schizophrenia.
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发表时间: 2014-07-24
期刊: NATURE
影响因子: 64.8
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DOI: 10.1001/archgenpsychiatry.2011.1519
发表时间: 2012-05-01
影响因子: --
作者:
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通讯作者: Shungu, Dikoma C.
通过质子磁共振波谱法测量从未治疗过的精神分裂症患者和健康对照的内侧前额叶皮质中的谷氨酸和谷氨酰胺。
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DOI: 10.1001/jamapsychiatry.2013.3939
发表时间: 2014-03
期刊: JAMA psychiatry
影响因子: 25.8
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发表时间: 1996
影响因子: 6.6
作者:
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