Calcium, vitamin D, and colon cancer.
Calcium, vitamin D, and colon cancer.
复制标题
钙、维生素 D 和结肠癌。
作者：
M. Lipkin;H. Newmark;C. Boone;G. Kelloff
摘要钙有助于上皮细胞在增殖周期的所有阶段和进入细胞分化阶段的过程；然而，细胞更新所需的细胞内钙浓度低于上皮细胞分化所需的钙浓度。钙的这些作用是通过与1，25-二羟基维生素D3、磷酸盐和脂肪酸的相互作用来调节的，所有这些都部分依赖于饮食摄入量。在啮齿动物模型中，增加饮食中的钙可以抑制结肠上皮细胞的过度增殖，这是由于结肠中存在的脂肪酸或胆汁酸水平增加所致。当致癌物诱导结肠上皮细胞过度增殖时，添加钙可抑制其过度增殖，并且在几种动物模型中，致癌物诱导的结肠癌的发生率随着膳食钙的增加而减少。一种营养压力饮食，旨在代表人类西方饮食中钙、磷、维生素D和脂肪的摄入量，导致啮齿动物结肠的过度增殖和增殖；这些影响随着饮食中钙水平的增加而减弱。据报道，在人体和啮齿动物的结肠粘膜中，随着钙水平的增加，鸟氨酸脱羧酶的水平也会降低。在家族性结肠癌风险增加的受试者中，口服补钙后结肠上皮细胞的过度增殖减少。在流行病学研究中，几位研究人员报告了饮食钙摄入量与结肠癌发病率之间的负相关关系。数据的外推表明，总钙摄入量超过1500至1800毫克/天具有保护作用。
Abstract Calcium contributes to the progression of epithelial cells through all phases of the proliferative cycle and into stages of cell differentiation; intracellular concentrations of calcium that are required for cell renewal, however, are lower than those required for epithelial-cell differentiation. These effects of calcium are modulated by interactions with 1,25-dihydroxy-vitamin D 3 , phosphate, and fatty acids, all of which are partly dependent on dietary intake. In rodent models, increased dietary calcium inhibited hyperproliferation of colon epithelial cells induced by increased levels of fatty acids or bile acids present in the colon. When carcinogens induced hyperproliferation of colon epithelial cells the hyperproliferation was decreased by added dietary calcium, and in several animal models the occurrence of carcinogen-induced carcinomas of the colon decreased with increased dietary calcium. A nutritional stress diet, designed to represent human Western dietary intake of calcium, phosphate, vitamin D, and fat, produced hyperproliferation and hyperplasia in the colons of rodents; these effects were reduced by increasing dietary levels of calcium. Decreased levels of ornithine decarboxylase also were reported in human and rodent colon mucosa exposed to increasing levels of calcium. In human subjects at increased risk for familial colon cancer, hyperproliferation of colon epithelial cells was reduced after oral dietary supplementation with calcium. In epidemiological studies, several investigators reported inverse correlations between levels of dietary calcium intake and the incidence of colon cancer. Extrapolation of the data have suggested a protective effect of total calcium intakes above 1500 to 1800 mg/day.
影响因子：
10.3
作者：
NEWMARK, HL;LIPKIN, M;MAHESHWARI, N
通讯作者：
MAHESHWARI, N
雌性 F344 大鼠中氧化偶氮甲烷诱导的结肠癌发生中膳食脂肪促进肿瘤：膳食脂肪数量和来源的影响。
DOI：
--
发表时间：
1984
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Reddy,BS;Maeura,Y
通讯作者：
Maeura,Y
胃肠癌易感性增加的生物标志物：在人类受试者癌症预防研究中的新应用。
影响因子：
11.2
作者：
Lipkin,M
通讯作者：
Lipkin,M