Novel polythiophene derivative for dual-channel cell imaging.
Novel polythiophene derivative for dual-channel cell imaging.
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用于双通道细胞成像的新型聚噻吩衍生物
作者：
荧光材料在了解微生物世界方面发挥着极其重要的作用。尽管已经合成了多种荧光材料，但仍迫切需要具有良好物理性能、低细胞毒性和多通道荧光成像能力的新型荧光材料。本文设计并合成了一种侧链上带有卟啉基团的新型聚噻吩衍生物（PT-OH-PPR）。所得PT-OH-PPR吸收和发射光谱范围宽，水溶性好，细胞毒性低。重要的是，它可以富集在A549细胞的细胞质中，并被两个激发波长（488 nm和559 nm）激发，这在双通道细胞成像中提供了有希望的应用。
Fluorescent materials play an extremely important role in understanding the microbiological world. New fluorescent materials which have good photophysical properties, low cytotoxicity, and multi-channel fluorescent imaging capability are still urgently needed, even though many kinds of fluorescent materials have already been synthesized. In this work, a new polythiophene derivative (PT-OH-PPR) modified with a porphyrin group in its side chain was designed and fabricated through FeCl3 oxidative polymerization. The obtained PT-OH-PPR has wide absorption and emission spectral range, good water solubility and low cytotoxicity. Importantly it could be enriched in the cytoplasm of A549 cells and be excited by two excitation wavelengths (488 nm and 559 nm), which provides a promising application in dual-channel cell imaging.
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用于细胞成像的水溶性聚噻吩衍生物的合成和表征
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