Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation.
Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation.
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DOI：
10.3389/fimmu.2016.00477
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发表时间：
2016
影响因子：
7.3
通讯作者：
Luther SA
中科院分区：
文献类型：
--
作者：
Barone F;Gardner DH;Nayar S;Steinthal N;Buckley CD;Luther SA
三级淋巴结构（TLS）是淋巴细胞、骨髓细胞和基质细胞的有组织聚集体，为获得性免疫反应提供异位枢纽。TLS与次级淋巴器官（SLO）具有相同的表型和功能特征;然而，它们需要持续的炎症信号才能出现，并且通常在自身免疫性疾病、慢性感染、癌症和器官移植的靶部位观察到。在过去的10年里，我们对基质成纤维细胞在SLO发育、组织和功能中的作用的理解取得了重要进展。一个复杂的和刻板的一系列事件调节成纤维细胞分化从胚胎生活在SLO的淋巴器官结构中观察到的成年人。相比之下，TLR相关成纤维细胞与出生后局部活化的间充质细胞不同，主要是在炎症和持续抗原提呈的情况下。因此，调节SLO与TLS发育的细胞和分子要求存在关键差异，最终影响基质和造血细胞功能。这些差异可能导致TLS在慢性炎症和恶性转化背景下的致病性质，并为TLS相关病理的治疗干预提供了机会。
Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid, and stromal cells that provide ectopic hubs for acquired immune responses. TLS share phenotypical and functional features with secondary lymphoid organs (SLO); however, they require persistent inflammatory signals to arise and are often observed at target sites of autoimmune disease, chronic infection, cancer, and organ transplantation. Over the past 10 years, important progress has been made in our understanding of the role of stromal fibroblasts in SLO development, organization, and function. A complex and stereotyped series of events regulate fibroblast differentiation from embryonic life in SLOs to lymphoid organ architecture observed in adults. In contrast, TLS-associated fibroblasts differentiate from postnatal, locally activated mesenchyme, predominantly in settings of inflammation and persistent antigen presentation. Therefore, there are critical differences in the cellular and molecular requirements that regulate SLO versus TLS development that ultimately impact on stromal and hematopoietic cell function. These differences may contribute to the pathogenic nature of TLS in the context of chronic inflammation and malignant transformation and offer a window of opportunity for therapeutic interventions in TLS associated pathologies.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
7.3
作者：
Astarita JL;Acton SE;Turley SJ
通讯作者：
Turley SJ
DOI：
10.4049/jimmunol.1203441
发表时间：
2014-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Beswick EJ;Johnson JR;Saada JI;Humen M;House J;Dann S;Qiu S;Brasier AR;Powell DW;Reyes VE;Pinchuk IV
通讯作者：
Pinchuk IV
影响因子：
32.4
作者：
Bannard O;Horton RM;Allen CD;An J;Nagasawa T;Cyster JG
通讯作者：
Cyster JG
影响因子：
64.8
作者：
Bouskra, Djahida;Brezillon, Christophe;Eberl, Gerard
通讯作者：
Eberl, Gerard