Stretchable Encapsulation Materials with High Dynamic Water Resistivity and Tissue-Matching Elasticity.
Stretchable Encapsulation Materials with High Dynamic Water Resistivity and Tissue-Matching Elasticity.
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DOI：
10.1021/acsami.2c03110
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发表时间：
2022-04-27
影响因子：
9.5
通讯作者：
Wang, Xudong
中科院分区：
文献类型：
--
作者：
Shao, Yan;Yan, Shan;Li, Jun;Silva-Pedraza, Zulmari;Zhou, Ting;Hsieh, Marvin;Liu, Bo;Li, Tong;Gu, Long;Zhao, Yunhe;Dong, Yutao;Yin, Bo;Wang, Xudong
关键词：
柔性植入式医疗器械（IMD）是一种新兴技术，可显著改善疾病治疗效果和患者生活质量。虽然IMD已经取得了许多进步，但不断应变的应用条件对包装材料提出了额外的要求，包装材料需要在生理环境中的动态应变下保持高拉伸性和高防水性。本工作报告了一种聚异丁烯（PIB）共混物为基础的弹性体，同时提供了一个组织样的弹性模量和优异的水电阻率下的动态应变。PIB共混物是具有不同分子量的两种类型的PIB分子的均匀混合物。该共混物实现了62 kPa的最佳杨氏模量，与软生物组织的杨氏模量相匹配。PIB共混物膜还表现出极低的水介电常数，从未应变到50%应变状态为1.6-2.9 g m-2 day-1。使用摩擦电纳米发电机（TENGs）测试了高柔性和动态水电阻率的组合。PIB混合包装的TENG能够在水中稳定运行2周，大大超过了Ecoflex提供的保护。这项工作提供了一个有前途的材料解决方案，包装柔性IMD，以实现稳定的性能，在紧张的生理环境。
Flexible implantable medical devices (IMDs) are an emerging technology that may substantially improve the disease treatment efficacy and quality of life of patients. While many advancements have been achieved in IMDs, the constantly straining application conditions impose extra requirements for the packaging material, which needs to retain both high stretchability and high water resistivity under dynamic strains in a physiological environment. This work reports a polyisobutylene (PIB) blend-based elastomer that simultaneously offers a tissue-like elastic modulus and excellent water resistivity under dynamic strains. The PIB blend is a homogeneous mixture of two types of PIB molecules with distinct molecular weights. The blend achieved an optimal Young’s modulus of 62 kPa, matching those of soft biological tissues. The PIB blend film also exhibited an extremely low water permittivity of 1.6–2.9 g m−2 day−1, from unstrained to 50% strain states. The combination of high flexibility and dynamic water resistivity was tested using triboelectric nanogenerators (TENGs). The PIB blend-packaged TENG was able to stably operate in water for 2 weeks, substantially surpassing the protection offered by Ecoflex. This work offered a promising material solution for packaging flexible IMDs to achieve stable performance in a strained physiological environment.
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影响因子：
17.6
作者：
Li J;Kang L;Yu Y;Long Y;Jeffery JJ;Cai W;Wang X
通讯作者：
Wang X
影响因子：
62.1
作者：
Nichols, Scott P.;Koh, Ahyeon;Storm, Wesley L.;Shin, Jae Ho;Schoenfisch, Mark H.
通讯作者：
Schoenfisch, Mark H.
影响因子：
2.8
作者：
Pons-Faudoa，Fernanda P.;Ballerini，Andrea;Grattoni，Alessandro
通讯作者：
Grattoni，Alessandro
影响因子：
3.2
作者：
Chaos, Ana;Sangroniz, Ainara;Etxeberria, Agustin
通讯作者：
Etxeberria, Agustin
影响因子：
17.4
作者：
Chen, Kuan;Ren, Jiayu;Zhang, Song
通讯作者：
Zhang, Song