Use of Organs from SARS-CoV-2 Infected Donors: Is It Safe? A Contemporary Review.
Use of Organs from SARS-CoV-2 Infected Donors: Is It Safe? A Contemporary Review.
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DOI：
10.1007/s40472-021-00343-0
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发表时间：
2021
影响因子：
2.1
通讯作者：
Lentine KL
中科院分区：
文献类型：
--
作者：
Kute VB;Fleetwood VA;Meshram HS;Guenette A;Lentine KL
随着2019冠状病毒病（COVID-19）康复者的患病率增加，确定这些捐赠者的器官是否以及何时可以安全使用是一个重要的优先事项。我们检查了目前对使用COVID-19康复供体的移植结果的了解。对PubMed和Google Scholar数据库进行了文献检索，以识别截至2021年10月8日发表的术语为“SARS-CoV 2”、“COVID-19”、“供体恢复”和“移植”的文章。我们发现了25份报告，详细描述了94名腹部和胸部移植受者，这些受者来自既往和活动性COVID-19感染的供体。在既往感染COVID-19的供体报告中，向受体传播和移植器官功能障碍的发生率较低。终末器官功能障碍和传播在活动性感染中更常见，但报道很少。需要标准化报告以更好地评估供体血液学、周期阈值和个体受体风险因素对术后结局的影响。现有报告表明，COVID-19供体的移植可能是可行和安全的，至少在短期随访中是如此。尽管如此，仍需要标准化的测试和管理协议，这些协议应根据现有资源量身定制。尽管增加COVID-19疫苗接种将降低供体来源的COVID-19风险并简化管理，但在持续的公共卫生紧急情况下仍需保持警惕。
As the prevalence of individuals with recovered coronavirus disease 2019 (COVID-19) increases, determining if and when organs from these donors can be safely used is an important priority. We examined current knowledge of outcomes of transplant using donors with recovered COVID-19. A literature search of PubMed and Google scholar databases was conducted to identify articles with terms “SARS-CoV2,” “COVID-19,” “donor recovered,” and “transplantation” published through 08/10/2021. We identified 25 reports detailing 94 recipients of both abdominal and thoracic transplants from donors with both prior and active COVID-19 infection. Rates of transmission to the recipient and of transplanted organ dysfunction were low among reports of donors with prior COVID-19 infection. End organ dysfunction and transmission were more common with active infection, although few reports are available. Standardized reporting is needed to better assess the impact of donor symptomatology, cycle thresholds, and individual recipient risk factors on postoperative outcomes. Available reports suggest that transplantation from COVID-19 donors may be feasible and safe, at least in short term follow-up. Nevertheless, there is a need for standardized testing and management protocols which should be tailored for available resources. While increased availability of COVID-19 vaccinations will mitigate risks of donor-derived COVID-19 and simplify management, continued vigilance is warranted during the ongoing public health emergency.
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影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
6.2
作者：
Bae S;McAdams-DeMarco MA;Massie AB;Ahn JB;Werbel WA;Brennan DC;Lentine KL;Durand CM;Segev DL
通讯作者：
Segev DL
影响因子：
6
作者：
Jan MY;Jawed AT;Barros N;Adebiyi O;Diez A;Fridell JA;Goggins WC;Yaqub MS;Anderson MD;Mujtaba MA;Taber TE;Mishler DP;Kumar V;Lentine KL;Sharfuddin AA
通讯作者：
Sharfuddin AA
影响因子：
1
作者：
Kucuk EV;Sit D;Kayabasi H;Tahra A;Sobay R;Yilmaz SNG;Karaoglu C;Ersoy Yesil E
通讯作者：
Ersoy Yesil E
影响因子：
1.3
作者：
Heinz, Nicole;Griesemer, Adam;Martinez, Mercedes
通讯作者：
Martinez, Mercedes