Genetic susceptibility in Parkinson's disease.
Genetic susceptibility in Parkinson's disease.
复制标题
帕金森病的遗传易感性。
DOI：
10.1016/j.bbadis.2008.11.008
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发表时间：
2009-07
影响因子：
6.2
通讯作者：
Singleton, Andrew
中科院分区：
文献类型：
--
作者：
Bras, Jose Miguel;Singleton, Andrew
人们希望，帕金森病（PD）的遗传基础的理解将导致欣赏疾病的分子发病机制，这反过来又将突出潜在的治疗干预点。人们还希望，这样的理解将允许在运动症状发作之前识别处于疾病风险中的个体。大量的工作已经在识别PD的遗传风险因素方面进行，其中一些工作，特别是那些专注于与PD单基因形式有关的基因的努力，虽然来之不易，但已经取得了成功。随着全基因组关联研究的应用，基因发现的新时代已经开始;这些有望促进复杂遗传疾病的常见遗传风险位点的鉴定。这是几种高通量技术中的第一种，这些技术有望揭示参与这种复杂的迟发性神经退行性疾病的（可能的）无数遗传因素。
It is hoped that an understanding of the genetic basis of Parkinson’s disease (PD) will lead to an appreciation of the molecular pathogenesis of disease, which in turn will highlight potential points of therapeutic intervention. It is also hoped that such an understanding will allow identification of individuals at risk for disease prior to the onset of motor symptoms. A large amount of work has already been performed in the identification of genetic risk factors for PD and some of this work, particularly those efforts that focus on genes implicated in monogenic forms of PD, have been successful, although hard won. A new era of gene discovery has begun, with the application of genome wide association studies; these promise to facilitate the identification of common genetic risk loci for complex genetic diseases. This is the first of several high throughput technologies that promise to shed light on the (likely) myriad genetic factors involved in this complex, late-onset neurodegenerative disorder.
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影响因子：
8.6
作者：
Clark, LN;Nicolai, A;Marder, K
通讯作者：
Marder, K
影响因子：
2.5
作者：
Izumi, Y;Morino, H;Kawakami, H
通讯作者：
Kawakami, H
影响因子：
9.9
作者：
Khan, NL;Scherfler, C;Piccini, P
通讯作者：
Piccini, P
影响因子：
9.9
作者：
Clark, L. N.;Ross, B. M.;Marder, K.
通讯作者：
Marder, K.
影响因子：
4.1
作者：
Farrer, Matthew J.;Stone, Jeremy T.;Wu, Ruey-Meei
通讯作者：
Wu, Ruey-Meei