Associations of lifetime concussion history and repetitive head impact exposure with resting-state functional connectivity in former collegiate American football players: An NCAA 15-year follow-up study.
Associations of lifetime concussion history and repetitive head impact exposure with resting-state functional connectivity in former collegiate American football players: An NCAA 15-year follow-up study.
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前大学足球运动员的终生脑震荡历史和重复的头部影响与静止状态功能连通性的关联：NCAA 15年的随访研究。
DOI：
10.1371/journal.pone.0273918
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
本研究的目的是检查前大学橄榄球运动员的终生脑震荡史 (CHx) 和终生重复性头部撞击暴露的高级指标与全脑和大规模功能网络（默认模式、背部注意力和额顶控制）之间的静息态功能连接 (rsFC) 之间的关联。完成至少一年大学橄榄球队比赛的个人有资格参加这项观察性队列研究（n = 48；年龄 36-41 岁；79.2% 白人/白人；踢足球 12.5±4.4 年；所有男性）。如果个体报告有活动性症状的精神病史/怀疑、参与研究程序的禁忌症（例如 MRI 安全问题）或无法旅行，则被排除在外。每个参与者都提供了脑震荡和踢足球的历史。根据先前的研究，以两种不同的方式对自我报告的脑震荡史进行分析：二分法“高”（≥3 次脑震荡；n = 28）与“低”（<3 次脑震荡；n = 20）；和四个顺序类别（0-1 次脑震荡 [n = 19]；2-4 次脑震荡 [n = 8]；5-7 次脑震荡 [n = 9]；以及 ≥8 次脑震荡 [n = 12]）。头部撞击暴露估计 (HIEE) 是根据结构化访谈捕获的足球比赛历史计算得出的。使用已建立的流程获取并预处理静息态 fMRI 和 T1 加权 MRI。接下来，使用 Seitzman 等人 (2020) 300-ROI 功能图集计算 rsFC。分别使用所有 ROI 和特定于网络的 ROI 计算全脑、网络内和网络间 rsFC。使用单独的多变量线性回归模型检查 CHx 和 HIEE 对 rsFC 值的影响，先验 α 设置为 0.05。我们观察到 rsFC 结果与 CHx 或 HIEE 之间没有统计学上显着的关联 (ps ≥ .12)。 CHx 和 HIEE 均与典型衰老和病理性衰老研究中观察到的神经特征无关。虽然 CHx 和重复性头部撞击与老年前运动员的大脑健康变化有关，但我们的初步结果表明，与 rsFC 的关联可能不存在于中年早期的前足球运动员中。
The objective of this study was to examine associations of lifetime concussion history (CHx) and an advanced metric of lifetime repetitive head impact exposure with resting-state functional connectivity (rsFC) across the whole-brain and among large-scale functional networks (Default Mode; Dorsal Attention; and Frontoparietal Control) in former collegiate football players. Individuals who completed at least one year of varsity collegiate football were eligible to participate in this observational cohort study (n = 48; aged 36–41 years; 79.2% white/Caucasian; 12.5±4.4 years of football played; all men). Individuals were excluded if they reported history/suspicion of psychotic disorder with active symptoms, contraindications to participation in study procedures (e.g., MRI safety concern), or inability to travel. Each participant provided concussion and football playing histories. Self-reported concussion history was analyzed in two different ways based on prior research: dichotomous “High” (≥3 concussions; n = 28) versus “Low” (<3 concussions; n = 20); and four ordinal categories (0–1 concussion [n = 19]; 2–4 concussions [n = 8]; 5–7 concussions [n = 9]; and ≥8 concussions [n = 12]). The Head Impact Exposure Estimate (HIEE) was calculated from football playing history captured via structured interview. Resting-state fMRI and T1-weighted MRI were acquired and preprocessed using established pipelines. Next, rsFC was calculated using the Seitzman et al., (2020) 300-ROI functional atlas. Whole-brain, within-network, and between-network rsFC were calculated using all ROIs and network-specific ROIs, respectively. Effects of CHx and HIEE on rsFC values were examined using separate multivariable linear regression models, with a-priori α set to 0.05. We observed no statistically significant associations between rsFC outcomes and either CHx or HIEE (ps ≥ .12). Neither CHx nor HIEE were associated with neural signatures that have been observed in studies of typical and pathological aging. While CHx and repetitive head impacts have been associated with changes in brain health in older former athletes, our preliminary results suggest that associations with rsFC may not be present in early midlife former football players.
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运动脑震荡的神经影像学：大脑结构和医疗清除功能的持续改变。
影响因子：
4.6
作者：
Churchill NW;Hutchison MG;Richards D;Leung G;Graham SJ;Schweizer TA
通讯作者：
Schweizer TA
影响因子：
6.8
作者：
Lau WK;Leung MK;Lee TM;Law AC
通讯作者：
Law AC
影响因子：
6.8
作者：
Langella S;Sadiq MU;Mucha PJ;Giovanello KS;Dayan E;Alzheimer’s Disease Neuroimaging Initiative
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
影响因子：
4.8
作者：
Guskiewicz, KM;Marshall, SW;Jordan, BD
通讯作者：
Jordan, BD
DOI：
10.1249/mss.0b013e31823240f2
发表时间：
2012-03-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Kerr, Zachary Y.;Marshall, Stephen W.;Guskiewicz, Kevin M.
通讯作者：
Guskiewicz, Kevin M.