Association between resting painless ST-segment depression with sudden cardiac death in middle-aged population: A prospective cohort study.
Association between resting painless ST-segment depression with sudden cardiac death in middle-aged population: A prospective cohort study.
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中年人群静息无痛 ST 段压低与心源性猝死之间的关联：一项前瞻性队列研究。
DOI：
10.1016/j.ijcard.2019.11.148
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发表时间：
2019-11
影响因子：
3.5
通讯作者：
Cheng Yun-Jiu
中科院分区：
文献类型：
--
作者：
Deng Xue-Qiong;Xu Xiong-Jun;Wu Su-Hua;Li Hai;Cheng Yun-Jiu
BackgoundSilent electrocardiographic ST change predicts future coronary heart disease (CHD) incidence and mortality, but the prognostic significance of painless ST-segment depression (STD) with respect to sudden cardiac death (SCD) in subjects without apparent CHD remain unclear. This study sought to test the association between non-ischemic resting STD and risk of SCD in the general population.MethodsA total of 14,935 middle-aged subjects from the prospective, population-based Atherosclerosis Risk in Communities (ARIC) study were included in this analysis. Cox models were used to estimate the hazard ratios (HRs) adjusted for possible confounding factors. STD was defined as ST-segment depression of ≥0.05 mV in two or more contiguous leads.ResultsA total of 626 sudden cardiac death occurred during the mean follow-up of 20.4 years. Compared with those without STD, subjects with resting painless STD of at least 0.05 mV had a significantly increased risk of developing SCD (adjusted HR, 1.45; 95% CI, 1.20 to 1.76), and those with STD ≥ 0.1 mV had even higher risk of SCD (adjusted HR, 1.90; 95% CI, 1.25 to 2.88). Significant interactions were present between gender and STD (P = .03), and between race and STD (P = .01). STD was significantly predictive of SCD in males (adjusted HR, 1.57; 95% CI, 1.22–2.01) and in whites (adjusted HR, 1.65; 95% CI, 1.27–2.14). STD in lateral leads and global leads were strong predictors of SCD.ConclusionsResting painless STD was an independent predictor of SCD in the middle-aged population without previously diagnosed CHD.
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DOI：
10.1161/circep.117.005485
发表时间：
2017-10
期刊：
Circulation. Arrhythmia and electrophysiology
影响因子：
--
作者：
O'Neal WT;Singleton MJ;Roberts JD;Tereshchenko LG;Sotoodehnia N;Chen LY;Marcus GM;Soliman EZ
通讯作者：
Soliman EZ
DOI：
10.1056/nejmoa1605086
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Khera AV;Emdin CA;Drake I;Natarajan P;Bick AG;Cook NR;Chasman DI;Baber U;Mehran R;Rader DJ;Fuster V;Boerwinkle E;Melander O;Orho-Melander M;Ridker PM;Kathiresan S
通讯作者：
Kathiresan S
影响因子：
168.9
作者：
Chan, Jasper Fuk-Woo;Yuan, Shuofeng;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
9
作者：
Channappanavar R;Perlman S
通讯作者：
Perlman S
影响因子：
5.7
作者：
Magnus J. Hagnäs;T. Lakka;S. Kurl;R. Rauramaa;T. Mäkikallio;K. Savonen;J. Laukkanen
通讯作者：
Magnus J. Hagnäs;T. Lakka;S. Kurl;R. Rauramaa;T. Mäkikallio;K. Savonen;J. Laukkanen