Myasthenia gravis complement activity is independent of autoantibody titer and disease severity.
Myasthenia gravis complement activity is independent of autoantibody titer and disease severity.
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DOI：
10.1371/journal.pone.0264489
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
O'Connor KC
中科院分区：
文献类型：
--
作者：
Fichtner ML;Hoarty MD;Vadysirisack DD;Munro-Sheldon B;Nowak RJ;O'Connor KC
在自身免疫性重症肌无力（MG）患者中发现乙酰胆碱受体（AChR）自身抗体，可通过激活经典补体途径直接参与疾病病理。自身免疫性疾病中补体途径的激活可导致继发性补体缺乏，导致在疾病活动期间由于消耗而导致补体活性降低。目前尚不清楚MG患者的补体活性是否与疾病活动性或循环致病性AChR自身抗体滴度相关。为了探索这种关联，作为鉴定候选生物标志物的一种手段，我们使用CH50溶血试验测量了AChR MG样品（N = 51）中的补体活性，然后测试了这些值与临床状态和AChR自身抗体滴度之间的关联。大多数研究对象（88.2%）的补体活性在健康对照组定义的范围内，而6名患者（11.8%）的补体活性降低。补体活性与疾病状态或AChR自身抗体滴度无显著相关性。
Acetylcholine receptor (AChR) autoantibodies, found in patients with autoimmune myasthenia gravis (MG), can directly contribute to disease pathology through activation of the classical complement pathway. Activation of the complement pathway in autoimmune diseases can lead to a secondary complement deficiency resulting in reduced complement activity, due to consumption, during episodes of disease activity. It is not clear whether complement activity in MG patients associates with measurements of disease activity or the titer of circulating pathogenic AChR autoantibodies. To explore such associations, as a means to identify a candidate biomarker, we measured complement activity in AChR MG samples (N = 51) using a CH50 hemolysis assay, then tested associations between these values and both clinical status and AChR autoantibody titer. The majority of the study subjects (88.2%) had complement activity within the range defined by healthy controls, while six patients (11.8%) showed reduced activity. No significant association between complement activity and disease status or AChR autoantibody titer was observed.
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