Towards a Framework for Better Understanding of Quiescent Cancer Cells.
Towards a Framework for Better Understanding of Quiescent Cancer Cells.
复制标题
建立更好地理解静止癌细胞的框架
作者：
Nik Nabil WN;Xi Z;Song Z;Jin L;Zhang XD;Zhou H;De Souza P;Dong Q;Xu H
静止癌细胞（QCC）是可逆地悬浮在G0期的癌细胞，具有重新进入细胞周期并启动肿瘤生长以及最终癌症复发和转移的能力。QCC也具有治疗挑战性，因为它们对选择性作用于增殖细胞的大多数常规癌症治疗具有抗性。考虑到QCC对癌症进展和治疗的重大影响，更好地理解适当的实验模型和QCC的评价是该领域的关键问题，对潜在的药理学干预有直接影响。在这里，这篇评论的重点是现有的和新兴的临床前模型和检测方法的QCCs，并讨论了各自的特点和应用范围。通过提供一个框架来选择适当的实验模型和研究方法，确定调节QCC存活和激活的关键参与者，并开发更有效的QCC靶向治疗药物，可能会减轻QCC的后果。
Quiescent cancer cells (QCCs) are cancer cells that are reversibly suspended in G0 phase with the ability to re-enter the cell cycle and initiate tumor growth, and, ultimately, cancer recurrence and metastasis. QCCs are also therapeutically challenging due to their resistance to most conventional cancer treatments that selectively act on proliferating cells. Considering the significant impact of QCCs on cancer progression and treatment, better understanding of appropriate experimental models, and the evaluation of QCCs are key questions in the field that have direct influence on potential pharmacological interventions. Here, this review focuses on existing and emerging preclinical models and detection methods for QCCs and discusses their respective features and scope for application. By providing a framework for selecting appropriate experimental models and investigative methods, the identification of the key players that regulate the survival and activation of QCCs and the development of more effective QCC-targeting therapeutic agents may mitigate the consequences of QCCs.
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影响因子：
4.7
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