ATP-binding cassette transporter A1 and HDL metabolism: effects of fatty acids.
ATP-binding cassette transporter A1 and HDL metabolism: effects of fatty acids.
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DOI：
10.1016/j.jnutbio.2011.03.001
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发表时间：
2012-01
影响因子：
5.6
通讯作者：
Koo, Sung I.
中科院分区：
文献类型：
--
作者：
Lee, Jiyoung;Park, Youngki;Koo, Sung I.
充足的证据表明膳食脂肪酸会改变血浆 HDL-C 水平。然而，脂肪酸影响的机制仍然难以捉摸。我们对 ATP 结合盒转运蛋白 A1 (ABCA1) 功能和调节的理解的最新进展为脂肪酸影响血浆 HDL-C 水平的机制提供了有价值的见解。 ABCA1 介导磷脂和游离胆固醇与载脂蛋白 A-I 的组装，这是 HDL 生物发生的关键步骤。研究表明，不饱和脂肪酸（而非饱和脂肪酸）在体外抑制 ABCA1 的表达。尽管有关脂肪酸介导的 ABCA1 表达调节机制的信息仍然有限且存在争议，但最近的证据表明不饱和脂肪酸在转录和转录后水平抑制 ABCA1 的表达。不饱和脂肪酸对 ABCA1 表达的转录抑制可能是 LXR 依赖性的。证据还表明组蛋白脱乙酰化可能在抑制中发挥作用。转录后，不饱和脂肪酸可能促进 ABCA1 蛋白降解，这可能涉及蛋白激酶对 ABCA1 的磷酸化。需要进一步的研究来更好地了解膳食脂肪酸在高密度脂蛋白代谢中的作用及其对心血管健康的影响。
Ample evidence indicates that dietary fatty acids alters the plasma levels of HDL-C. However, the mechanisms underlying the effects of fatty acids still remain elusive. Recent advances in our understanding of ATP binding cassette transporter A1 (ABCA1) function and regulation have provided a valuable insight into the mechanisms by which fatty acids may affect plasma HDL-C levels. ABCA1 mediates the assembly of phospholipids and free cholesterol with apolipoprotein A-I, which is a critical step for HDL biogenesis. Studies have shown that unsaturated fatty acids, but not saturated fatty acids, repress the expression of ABCA1 in vitro. Although information on mechanisms for the fatty acid-mediated regulation of ABCA1 expression is still limited and controversial, recent evidence suggests that unsaturated fatty acids inhibit the expression of ABCA1 at the transcriptional and posttranscriptional levels. The transcriptional repression of ABCA1 expression by unsaturated fatty acids is likely LXR-dependent. Evidence also suggests that histone deacetylation may play a role in the repression. Posttranscriptionally, unsaturated fatty acids may facilitate ABCA1 protein degradation, which may involve phosphorylation of ABCA1 by protein kinases. Further studies are warranted to better understand the role of dietary fatty acids in HDL metabolism and their effects on cardiovascular health.
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影响因子：
6.5
作者：
Basso, F;Freeman, L;Brewer, HB
通讯作者：
Brewer, HB
影响因子：
2.9
作者：
CASTRO, GR;FIELDING, CJ
通讯作者：
FIELDING, CJ
DOI：
10.1016/0005-2760(81)90253-8
发表时间：
1981-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
BLANCHE, PJ;GONG, EL;NICHOLS, AV
通讯作者：
NICHOLS, AV
影响因子：
4.8
作者：
Arakawa, R;Yokoyama, S
通讯作者：
Yokoyama, S
影响因子：
30.8
作者：
Bodzioch, M;Orsó, E;Schmitz, G
通讯作者：
Schmitz, G