miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer.
miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer.
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miR-6745-TIMP1轴抑制胃癌细胞生长和转移
DOI：
10.18632/aging.203688
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发表时间：
2021-11-14
期刊：
影响因子：
--
通讯作者：
Liao XH
中科院分区：
文献类型：
--
作者：
Liu H;Xiang Y;Zong QB;Zhang XY;Wang ZW;Fang SQ;Zhang TC;Liao XH
组织抑制剂基质金属蛋白酶1 （TIMP1）已被报道为结肠癌的肿瘤致癌基因。然而，对TIMP1在胃癌中的生物学作用知之甚少。本研究中，我们发现胃癌组织中TIMP1的表达较正常胃组织上调。TIMP1被证实是miR-6745的直接靶点，沉默TIMP1模拟了miR-6745在GC细胞中的作用。进一步的机制研究表明，miR-6745通过靶向TIMP1抑制Wnt/β-catenin通路，从而抑制细胞增殖、迁移和侵袭。此外，通过对GC组织的分析，在42个GC组织中发现miR-6745与TIMP1呈负相关。我们的研究结果表明，miR-6745-TIMP1轴调节Wnt/βcatenin信号传导，参与GC肿瘤发生，并为阻止GC进展提供了潜在的治疗靶点。
Tissue inhibitor matrix metalloproteinase 1 (TIMP1) has been reported to act as a tumor oncogene in colon cancer. However, little is known about the biological role of TIMP1 in gastric cancer. In this study, we found that the expression of TIMP1 in GC tissues was upregulated compared with the normal gastric tissues. TIMP1 was confirmed as a direct target of miR-6745 and silencing TIMP1 mimicked the effects of miR-6745 in GC cells. Further mechanism studies have shown that miR-6745 inhibits the Wnt/β-catenin pathway by targeting TIMP1, thereby inhibiting cell proliferation, migration and invasion. In addition, through the analysis of GC tissues, a negative correlation between miR-6745 and TIMP1 was found in 42 GC tissues. Our findings indicate that the miR-6745-TIMP1 axis regulates Wnt/βcatenin signaling and participates in GC tumorigenesis and provide a potential therapeutic target for preventing GC progression.
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影响因子：
3.5
作者：
Flanagan DJ;Austin CR;Vincan E;Phesse TJ
通讯作者：
Phesse TJ
TIMP1是通过FAK-PI3K/AKT和MAPK通路预测结肠癌进展和转移的预后标志物。
DOI：
10.1186/s13046-016-0427-7
发表时间：
2016-09-20
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Song G;Xu S;Zhang H;Wang Y;Xiao C;Jiang T;Wu L;Zhang T;Sun X;Zhong L;Zhou C;Wang Z;Peng Z;Chen J;Wang X
通讯作者：
Wang X
影响因子：
24.5
作者：
Loyer X;Paradis V;Hénique C;Vion AC;Colnot N;Guerin CL;Devue C;On S;Scetbun J;Romain M;Paul JL;Rothenberg ME;Marcellin P;Durand F;Bedossa P;Prip-Buus C;Baugé E;Staels B;Boulanger CM;Tedgui A;Rautou PE
通讯作者：
Rautou PE
影响因子：
4.5
作者：
Wang, Jubo;Quan, Yu;Dong, Danfeng
通讯作者：
Dong, Danfeng
影响因子：
5.4
作者：
Chakrabarti, O;Veeraraghavalu, K;Krishna, S
通讯作者：
Krishna, S