Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience.
Health status outcomes after spontaneous coronary artery dissection and comparison with other acute myocardial infarction: The VIRGO experience.
复制标题
DOI：
10.1371/journal.pone.0265624
复制
发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Krumholz HM
中科院分区：
文献类型：
--
作者：
Murugiah K;Chen L;Dreyer RP;Bouras G;Safdar B;Khera R;Lu Y;Spatz ES;Ng VG;Gupta A;Bueno H;Tweet MS;Spertus JA;Hayes SN;Lansky A;Krumholz HM
关于自发性冠状动脉夹层（SCAD）后健康状况结果的数据有限。利用恢复差异：性别对年轻 AMI 患者结局的作用 (VIRGO) 研究，我们使用标准化健康状况工具对 SCAD 患者和其他急性心肌梗死 (AMI) 患者就诊时（基线）、1 个月和 12 个月进行了比较。在 3572 名 ≤ 55 岁的 AMI 患者中，67 名患有 SCAD。 SCAD 患者较年轻（中位年龄 (IQR) 45 (40.5–51) 岁，其他 AMI 为 48 (44–52) 岁，p = 0.003），女性较多（92.5% vs. 66.6%），受过大学教育（73.1% vs. 51.7%），家庭收入 > 100,000 美元（43.3% vs. 17.7%） （所有 SCAD 患者基线时均值较高）。 ± SD Short Form-12 [SF-12] 身体成分评分 [PCS]（48.7±10.2 对比 43.8±12.1，p<0.001）和心理成分评分 [MCS]（49.6±12.4 对比 45.4±12.5，p = 0.008），以及 12 个月时的 [PCS（50.1±9.0 对比 43.8±12.1，p <0.001） 44.3±12.3， p<0.001）和 MCS（53±10.1 与 50.2±11.0，p = 0.045）]。欧洲生活质量量表 [EQ-5D] VAS 和 EQ-5D 指数评分在基线时相似，但在 12 个月时 SCAD 评分较高（EQ-5D VAS：82.2±10.2 与 72.3±21.0，p<0.001； EQ-5D指数得分； 90.2±15.3 与 83.7±19.8，p = 0.012）。 SCAD 患者具有更好的基线西雅图心绞痛问卷 [SAQ] 身体限制（88.8±20.1 与 81.2±25.4，p = 0.017）。 12 个月时，SCAD 患者有更好的身体限制（98.0±8.5 vs. 91.4±18.8，p = 0.007）、心绞痛频率（96.4±8.8 vs. 91.3±16.8，p = 0.018）和生活质量评分（80.7±14.7 vs 72.2±23.2，p = 0.005）。各组之间从基线到 12 个月的健康状况变化幅度没有统计学差异。调整好时间和时间后 合并症大多数健康状况结果仍然没有差异。在大多数健康状况工具上，SCAD 患者的表现略好于其他 AMI 患者，并且 12 个月的健康状况恢复情况相似。更好的赛前健康状况表明需要修改运动处方和心脏康复方案，以更好地帮助这些身体活跃的人群恢复。
Data on health status outcomes after spontaneous coronary artery dissection (SCAD) are limited. Using the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) study we compared patients with SCAD and other acute myocardial infarction (AMI) at presentation (baseline), 1-month, and-12 months using standardized health status instruments. Among 3572 AMI patients ≤ 55 years, 67 had SCAD. SCAD patients were younger (median age (IQR) 45 (40.5–51) years vs. 48 (44–52) in other AMI, p = 0.003), more often female (92.5% vs. 66.6%), have college education (73.1% vs. 51.7%) and household income >$100,000 (43.3% vs. 17.7% (All p<0.001). SCAD patients at baseline had higher mean ± SD Short Form-12 [SF-12] physical component scores [PCS] (48.7±10.2 vs. 43.8±12.1, p<0.001) and mental component scores [MCS] (49.6±12.4 vs. 45.4±12.5, p = 0.008), and at 12-months [PCS (50.1±9.0 vs. 44.3±12.3, p<0.001) and MCS (53±10.1 vs 50.2±11.0, p = 0.045)]. The Euro-Quality of Life Scale [EQ-5D] VAS and EQ-5D index scores were similar at baseline, but higher at 12-months for SCAD (EQ-5D VAS: 82.2±10.2 vs. 72.3±21.0, p<0.001; EQ-5D index scores; 90.2±15.3 vs. 83.7±19.8, p = 0.012). SCAD patients had better baseline Seattle Angina Questionnaire [SAQ] physical limitation (88.8±20.1 vs. 81.2±25.4, p = 0.017). At 12-months SCAD patients had better physical limitation (98.0±8.5 vs. 91.4±18.8, p = 0.007), angina frequency (96.4±8.8 vs. 91.3±16.8, p = 0.018) and quality of life scores (80.7±14.7 vs 72.2±23.2, p = 0.005). Magnitude of change in health status from baseline to 12-months was not statistically different between the groups. After adjustment for time and comorbidities there remained no difference in most health status outcomes. SCAD patients fare marginally better than other AMI patients on most health status instruments and have similar 12-month health status recovery. Better pre-event health status suggests a need to modify exercise prescriptions and cardiac rehabilitation protocols to better assist this physically active population to recover.
登录
查看更多内容
DOI：
10.1161/circoutcomes.109.928713
发表时间：
2010-11-01
影响因子：
6.9
作者：
Lichtman, Judith H.;Lorenze, Nancy P.;Krumholz, Harlan M.
通讯作者：
Krumholz, Harlan M.
影响因子：
37.8
作者：
Spertus, JA;Jones, P;Fihn, SD
通讯作者：
Fihn, SD
影响因子：
12.7
作者：
Braveman, Paula A.;Cubbin, Catherine;Pamuk, Elsie
通讯作者：
Pamuk, Elsie
影响因子：
24
作者：
Saw, Jacqueline;Humphries, Karin;Mancini, John
通讯作者：
Mancini, John
DOI：
10.1161/circoutcomes.114.000967
发表时间：
2014-09
期刊：
Circulation. Cardiovascular quality and outcomes
影响因子：
--
作者：
Chan PS;Jones PG;Arnold SA;Spertus JA
通讯作者：
Spertus JA