DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.
DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.
复制标题
DOI：
10.1093/nar/gkl460
复制
发表时间：
2006
影响因子：
14.9
通讯作者：
Fuller-Pace FV
中科院分区：
文献类型：
--
作者：
Fuller-Pace FV
DExD/H盒蛋白家族包括大量在RNA代谢中发挥重要作用的蛋白质。该家族的成员已被证明作为RNA解旋酶或解旋酶，在需要调节RNA结构的细胞过程中使用来自ATP水解的能量来解旋RNA结构或解离RNA-蛋白质复合物。然而，很明显，这个家族的几个成员是多功能的，除了在前mRNA加工等过程中充当RNA解旋酶外，还在转录调控中发挥重要作用。在这篇综述中，我将集中于RNA解旋酶A（Dhx 9），DP 103（Ddx 20），p68（Ddx 5）和p72（Ddx 17），这些蛋白质有大量的证据表明它们在转录中起着重要的作用，通常作为辅激活子或辅抑制子，通过与转录机制的关键组分，如CREB结合蛋白，p300，RNA聚合酶II和组蛋白脱乙酰酶。
The DExD/H box family of proteins includes a large number of proteins that play important roles in RNA metabolism. Members of this family have been shown to act as RNA helicases or unwindases, using the energy from ATP hydrolysis to unwind RNA structures or dissociate RNA–protein complexes in cellular processes that require modulation of RNA structures. However, it is clear that several members of this family are multifunctional and, in addition to acting as RNA helicases in processes such as pre-mRNA processing, play important roles in transcriptional regulation. In this review I shall concentrate on RNA helicase A (Dhx9), DP103 (Ddx20), p68 (Ddx5) and p72 (Ddx17), proteins for which there is a strong body of evidence showing that they play important roles in transcription, often as coactivators or corepressors through their interaction with key components of the transcriptional machinery, such as CREB-binding protein, p300, RNA polymerase II and histone deacetylases.
登录
查看更多内容
影响因子：
6.8
作者：
GORBALENYA, AE;KOONIN, EV
通讯作者：
KOONIN, EV
影响因子：
56.9
作者：
Fairman, ME;Maroney, PA;Jankowsky, E
通讯作者：
Jankowsky, E
影响因子：
5.3
作者：
Aratani, S;Fujii, R;Nakajima, T
通讯作者：
Nakajima, T
影响因子：
56.9
作者：
Auboeuf, D;Hönig, A;O'Malley, BW
通讯作者：
O'Malley, BW
影响因子：
5.3
作者：
Bond, AT;Mangus, DA;Jacobson, A
通讯作者：
Jacobson, A