Does tetanus vaccination contribute to reduced severity of the COVID-19 infection?
Does tetanus vaccination contribute to reduced severity of the COVID-19 infection?
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DOI：
10.1016/j.mehy.2020.110395
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发表时间：
2021-01
影响因子：
4.7
通讯作者：
Sukumar SR
中科院分区：
文献类型：
--
作者：
Rickett CD;Maschhoff KJ;Sukumar SR
我们向积极设计临床试验并推荐公共卫生指南以控制大流行的科学界提出假设-“破伤风疫苗接种可能有助于降低COVID-19感染的严重程度”-并敦促进一步研究以验证或无效破伤风类毒素疫苗对COVID-19的有效性。这一假设是由一个可解释的人工智能系统在开放的公共生物医学数据集上揭示的。作为科学严谨性的基础，我们描述了数据和人工智能系统，记录了用于推导假设的出处和方法，并从最近的研究中收集了潜在的相关数据/证据。我们的结论是，虽然相关性可能不是因果关系的原因，多个来源的相关性不仅仅是一个偶然的巧合，值得进一步深入研究。
We present the hypothesis to the scientific community actively designing clinical trials and recommending public health guidelines to control the pandemic that – “Tetanus vaccination may be contributing to reduced severity of the COVID-19 infection” – and urge further research to validate or invalidate the effectiveness of the tetanus toxoid vaccine against COVID-19. This hypothesis was revealed by an explainable artificial intelligence system unleashed on open public biomedical datasets. As a foundation for scientific rigor, we describe the data and the artificial intelligence system, document the provenance and methodology used to derive the hypothesis and also gather potentially relevant data/evidence from recent studies. We conclude that while correlations may not be reason for causation, correlations from multiple sources is more than a serendipitous coincidence that is worthy of further and deeper investigation.
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影响因子：
14.9
作者：
Kim S;Chen J;Cheng T;Gindulyte A;He J;He S;Li Q;Shoemaker BA;Thiessen PA;Yu B;Zaslavsky L;Zhang J;Bolton EE
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影响因子：
14.9
作者：
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DOI：
10.1093/bioinformatics/btt765
发表时间：
2014-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
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作者：
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通讯作者：
Jenkinson AM
影响因子：
5
作者：
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通讯作者：
Kodzius, Rimantas
DOI：
10.11606/s1518-8787.2018052001199
发表时间：
2018-01-01
期刊：
Revista de Saúde Pública
影响因子：
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作者：
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通讯作者：
Sato, Ana Paula Sayuri