The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases.
The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases.
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DOI：
10.3390/ijms21249739
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发表时间：
2020-12-20
影响因子：
5.6
通讯作者：
Martinez-Fierro ML
中科院分区：
文献类型：
--
作者：
Cabral-Pacheco GA;Garza-Veloz I;Castruita-De la Rosa C;Ramirez-Acuña JM;Perez-Romero BA;Guerrero-Rodriguez JF;Martinez-Avila N;Martinez-Fierro ML
基质金属蛋白酶（MMPs）是一类依赖锌的细胞外基质（ECM）重塑内肽酶家族，几乎能够降解细胞外基质的所有成分。细胞外基质的降解至关重要，因为它与胚胎发育和血管生成相关，还参与细胞修复和组织重塑。当基质金属蛋白酶的表达发生改变时，会导致细胞外基质的异常降解。这是慢性退行性疾病以及糖尿病引发的血管并发症发展的初始原因。此外，这一过程与神经退行性变和癌症进展也有关系。在细胞外基质中，基质金属蛋白酶组织抑制剂（TIMPs）可抑制基质金属蛋白酶的蛋白水解活性。TIMPs是细胞外基质周转、组织重塑和细胞行为的重要调节因子。因此，TIMPs（与MMPs类似）可调节血管生成、细胞增殖和凋亡。MMPs与TIMPs之间平衡的破坏与多种疾病的病理生理过程和进展有关。本综述聚焦于MMPs（如MMP - 2和MMP - 9）和TIMPs（如TIMP - 1和TIMP - 3）在生理过程中的作用，以及它们的异常调节与人类疾病的关联。同时也探讨了在开发针对MMPs的新疗法中，目前抑制MMPs的策略和机制。
Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost every component of the ECM. The degradation of the ECM is of great importance, since it is related to embryonic development and angiogenesis. It is also involved in cell repair and the remodeling of tissues. When the expression of MMPs is altered, it can generate the abnormal degradation of the ECM. This is the initial cause of the development of chronic degenerative diseases and vascular complications generated by diabetes. In addition, this process has an association with neurodegeneration and cancer progression. Within the ECM, the tissue inhibitors of MMPs (TIMPs) inhibit the proteolytic activity of MMPs. TIMPs are important regulators of ECM turnover, tissue remodeling, and cellular behavior. Therefore, TIMPs (similar to MMPs) modulate angiogenesis, cell proliferation, and apoptosis. An interruption in the balance between MMPs and TIMPs has been implicated in the pathophysiology and progression of several diseases. This review focuses on the participation of both MMPs (e.g., MMP-2 and MMP-9) and TIMPs (e.g., TIMP-1 and TIMP-3) in physiological processes and on how their abnormal regulation is associated with human diseases. The inclusion of current strategies and mechanisms of MMP inhibition in the development of new therapies targeting MMPs was also considered.
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DOI：
10.1186/1477-7827-8-62
发表时间：
2010-06-16
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Anumba DO;El Gelany S;Elliott SL;Li TC
通讯作者：
Li TC
影响因子：
37.8
作者：
Ali MA;Cho WJ;Hudson B;Kassiri Z;Granzier H;Schulz R
通讯作者：
Schulz R
影响因子：
16.6
作者：
Ambadipudi S;Biernat J;Riedel D;Mandelkow E;Zweckstetter M
通讯作者：
Zweckstetter M
影响因子：
11.2
作者：
Andarawewa, KL;Motrescu, ER;Rio, MC
通讯作者：
Rio, MC
影响因子：
8
作者：
Ahonen, M;Poukkula, M;Kähäri, VM
通讯作者：
Kähäri, VM