Utility of childhood glucose homeostasis variables in predicting adult diabetes and related cardiometabolic risk factors: the Bogalusa Heart Study.
Utility of childhood glucose homeostasis variables in predicting adult diabetes and related cardiometabolic risk factors: the Bogalusa Heart Study.
复制标题
DOI：
10.2337/dc09-1635
复制
发表时间：
2010-03
期刊：
影响因子：
16.2
通讯作者：
Berenson GS
中科院分区：
文献类型：
--
作者：
Nguyen QM;Srinivasan SR;Xu JH;Chen W;Kieltyka L;Berenson GS
本研究探讨了儿童时期葡萄糖稳态变量（葡萄糖、胰岛素和胰岛素抵抗指数[胰岛素抵抗的稳态模型评估{HOMA-IR}]）在预测成年期糖尿病前期和2型糖尿病及相关心脏代谢危险因素中的作用。这项回顾性队列研究包括血糖正常者（n = 1058）、糖尿病前期患者（n = 37）和2型糖尿病患者（n = 25），年龄在19-39岁之间，自儿童期起平均随访17年。在儿童时期葡萄糖稳态变量排名最高（前五分之一）的人中，至少有50%的人在成年后保持了高于第60百分位的高排名。在多变量模型中，成年期葡萄糖稳态变量的最佳预测因子是儿童期BMI Z评分和儿童期BMI Z评分的变化，其次是相应的儿童期葡萄糖、胰岛素和HOMA-IR水平。此外，胰岛素和HOMA-IR水平最高的十分之一的儿童患前驱糖尿病的可能性分别是其他儿童的2.85倍和2.55倍；血糖、胰岛素和HOMA-IR水平最高的十分之一儿童与其他儿童相比，分别是3.28倍、5.54倍和5.84倍，患糖尿病的可能性更大，与BMI Z评分、基线BMI Z评分和总胆固醇与高密度脂蛋白比值的变化无关。此外，葡萄糖稳态变量不良水平（前五分之一与其余五分之一）的儿童，在高血糖、高甘油三酯血症和代谢综合征等疾病中，表现出明显更高的患病率。儿童时期葡萄糖稳态变量的不良水平不仅会持续到成年，而且还可以预测成人糖尿病前期和2型糖尿病，并与心脏代谢危险因素有关。
This study examines the usefulness of childhood glucose homeostasis variables (glucose, insulin, and insulin resistance index [homeostasis model assessment of insulin resistance {HOMA-IR}]) in predicting pre-diabetes and type 2 diabetes and related cardiometabolic risk factors in adulthood. This retrospective cohort study consisted of normoglycemic (n = 1,058), pre-diabetic (n = 37), and type 2 diabetic (n = 25) adults aged 19–39 years who were followed on average for 17 years since childhood. At least 50% of the individuals who ranked highest (top quintile) in childhood for glucose homeostasis variables maintained their high rank by being above the 60th percentile in adulthood. In a multivariate model, the best predictors of adulthood glucose homeostasis variables were the change in BMI Z score from childhood to adulthood and childhood BMI Z score, followed by the corresponding childhood levels of glucose, insulin, and HOMA-IR. Further, children in the top decile versus the rest for insulin and HOMA-IR were 2.85 and 2.55 times, respectively, more likely to develop pre-diabetes; children in the top decile versus the rest for glucose, insulin, and HOMA-IR were 3.28, 5.54, and 5.84 times, respectively, more likely to develop diabetes, independent of change in BMI Z score, baseline BMI Z score, and total-to-HDL cholesterol ratio. In addition, children with adverse levels (top quintile versus the rest) of glucose homeostasis variables displayed significantly higher prevalences of, among others, hyperglycemia, hypertriglyceridemia, and metabolic syndrome. Adverse levels of glucose homeostasis variables in childhood not only persist into adulthood but also predict adult pre-diabetes and type 2 diabetes and relate to cardiometabolic risk factors.
登录
查看更多内容
糖尿病前和2型糖尿病患者以来代谢综合征的风险变量的变化：Bogalusa心脏研究。
影响因子：
16.2
作者：
Nguyen, Quoc Manh;Srinivasan, Sathanur R.;Xu, Ji-Hua;Chen, Wei;Berenson, Gerald S.
通讯作者：
Berenson, Gerald S.
影响因子：
16.2
作者：
Fox, CS;Sullivan, L;Wilson, PWF
通讯作者：
Wilson, PWF
影响因子：
7.7
作者：
Franks, Paul W.;Hanson, Robert L.;Looker, Helen C.
通讯作者：
Looker, Helen C.
影响因子：
4.4
作者：
RONNEMAA, T;KNIP, M;AKERBLOM, HK
通讯作者：
AKERBLOM, HK
影响因子：
168.9
作者：
Weiss, R;Dufour, S;Caprio, S
通讯作者：
Caprio, S