Inferring cerebrovascular changes from latencies of systemic and intracranial pulses: a model-based latency subtraction algorithm.
Inferring cerebrovascular changes from latencies of systemic and intracranial pulses: a model-based latency subtraction algorithm.
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DOI：
10.1038/jcbfm.2008.160
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发表时间：
2009-04
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影响因子：
--
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根据脉搏波传播理论，脑血流速度（CBFV）脉搏波潜伏期的变化反映了脑血管的病理生理变化。相对于ECG QRS对CBFV脉冲开始计时是可行的。然而，它引入了颅外起源的混杂因素来表征脑血管。目前的工作介绍了一种方法，减少混杂影响的CBFV潜伏期。这种校正方法是基于对CBFV潜伏期和全身动脉血压（ABP）脉搏潜伏期之间的关系进行建模。它是测试使用现有的数据集CBFV和ABP从14个正常受试者进行压力袖带测试下常氧和急性缺氧状态。结果表明，所提出的CBFV潜伏期校正方法产生了对脑血管变化的更准确的测量，其中心跳间CBFV与CBFV潜伏期时间序列之间的正相关性得到了改善，例如，在常氧下，组平均袖带放气痕迹的相关系数从0.643提高到0.836。总之，目前的工作表明，减去全身ABP潜伏期改善CBFV潜伏期测量，这反过来又改善了脑血管变化的表征。
Changes in cerebral blood flow velocity (CBFV) pulse latency reflect pathophysiological changes of the cerebral vasculature based on the theory of pulse wave propagation. Timing CBFV pulse onset relative to ECG QRS is practical. However, it introduces confounding factors of extracranial origins for characterizing the cerebral vasculature. The present work introduces an approach of reducing confounding influences on CBFV latency. This correction approach is based on modeling the relationship between CBFV latency and systemic arterial blood pressure (ABP) pulse latency. It is tested using an existing data set of CBFV and ABP from 14 normal subjects undergoing pressure cuff tests under both normoxic and acute hypoxic states. The results show that the proposed CBFV latency correction approach produces a more accurate measure of cerebral vascular changes with an improved positive correlation between beat-to-beat CBFV and the CBFV latency time series, e.g., correlation coefficient raised from 0.643 to 0.836 for group-averaged cuff-deflation traces at normoxia. In conclusion, the present work suggests that subtraction of systemic ABP latency improves CBFV latency measurements, which in turn improves characterization of cerebral vascular changes.
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影响因子：
3.2
作者：
Panerai, RB;Deverson, ST;Evans, DH
通讯作者：
Evans, DH
影响因子：
11
作者：
Czosnyka, M;Smielewski, P;Pickard, JD
通讯作者：
Pickard, JD
影响因子：
8.3
作者：
AASLID, R;LINDEGAARD, KF;NORNES, H
通讯作者：
NORNES, H
影响因子：
4.6
作者：
Afonso, VX;Tompkins, WJ;Luo, S
通讯作者：
Luo, S
DOI：
10.1097/00004647-199710000-00015
发表时间：
1997-10-01
影响因子：
6.3
作者：
Michel, E;Hillebrand, S;Jorch, G
通讯作者：
Jorch, G