Liver diffusivity in healthy volunteers and patients with chronic liver disease: comparison of breathhold and free-breathing techniques.
Liver diffusivity in healthy volunteers and patients with chronic liver disease: comparison of breathhold and free-breathing techniques.
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DOI：
10.1002/jmri.22748
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发表时间：
2012-01
影响因子：
4.4
通讯作者：
Qayyum, Aliya
中科院分区：
文献类型：
--
作者：
Eatesam, Mamak;Noworolski, Susan M.;Tien, Phyllis C.;Nystrom, Michelle;Dodge, Jennifer L.;Merriman, Raphael B.;Qayyum, Aliya
关键词：
To compare liver ADC obtained with breath-hold and free-breathing diffusion weighted imaging (DWI) in healthy volunteers and patients with liver disease. Twenty-eight subjects, 12 healthy volunteers and 16 patients (9 NAFLD, 7 chronic active HCV), underwent breath-hold (BH) and free-breathing (FB) DWI MRI at 1.5T. Pearson’s correlation coefficient was used to determine correlation while paired t-tests assessed differences between BH and FB ADC. Estimated bias was calculated using the Bland-Altman method. Liver ADC (×10−3 mm2/sec) was lower on BH for all groups (mean difference 0.36±0.20; p<0.01). ADC was higher in healthy volunteers (BH 1.80±0.18; FB 2.24±0.20) compared to NAFLD patients (BH 1.43±0.27; FB 1.78±0.28) (p<0.001) and HCV patients (BH 1.63±0.191; FB 1.88±0.12). Overall correlation between BH and FB ADC was (r =0.75), greatest in NAFLD (r =0.90) compared to the correlation in HCV (r =0.24) and healthy subjects (r =0.34). Bland-Altman plots did not show agreement in mean absolute difference and estimated bias between subjects. Correlation between BH and FB liver ADC is moderate indicating that BH and FB should not be used interchangeably. Additionally, the lower ADC values in BH versus FB should be accounted for when comparing different liver DWI studies.
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DOI：
10.2463/mrms.4.175
发表时间：
2005-12-31
期刊：
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
影响因子：
--
作者：
Naganawa, Shinji;Kawai, Hisashi;Ishigaki, Takeo
通讯作者：
Ishigaki, Takeo
DOI：
10.1046/j.1440-1681.2002.03686.x
发表时间：
2002-07-01
影响因子：
2.9
作者：
Ludbrook, J
通讯作者：
Ludbrook, J
影响因子：
5.4
作者：
Barkan, SE;Melnick, SL;Feldman, J
通讯作者：
Feldman, J
DOI：
10.1007/s10334-007-0084-0
发表时间：
2007-10-01
影响因子：
2.3
作者：
Nasu, Katsuhiro;Kuroki, Yoshifumi;Minami, Manabu
通讯作者：
Minami, Manabu
影响因子：
1.9
作者：
Kok, T;van der Jagt, EJ;Boeve, WJ
通讯作者：
Boeve, WJ