Kinetic Changes of Peripheral Blood Monocyte Subsets and Expression of Co-Stimulatory Molecules during Acute Dengue Virus Infection.
Kinetic Changes of Peripheral Blood Monocyte Subsets and Expression of Co-Stimulatory Molecules during Acute Dengue Virus Infection.
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急性登革病毒感染时外周血单核细胞亚群及共刺激分子表达的动态变化
DOI：
10.3390/pathogens10111458
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发表时间：
2021-11-10
期刊：
影响因子：
--
通讯作者：
Pattanapanyasat K
中科院分区：
文献类型：
--
作者：
Lertjuthaporn S;Keawvichit R;Polsrila K;Sukapirom K;Chuansumrit A;Chokephaibulkit K;Ansari AA;Khowawisetsut L;Pattanapanyasat K
Monocytes, one of the main target cells for dengue virus (DENV) infection, contribute to the resolution of viremia and to pathogenesis. We performed a longitudinal study by a detailed phenotypic comparison of classical (CD14++CD16−, non-classical (CD14+CD16++) and intermediate (CD14++CD16+) monocyte subsets in blood samples from dengue fever (DF) to the severe dengue hemorrhagic fever (DHF) and healthy individuals. Various costimulatory molecules of CD40, CD80, CD86 and inducible costimulatory ligand (ICOSL) expressed on these three monocyte subsets were also analyzed. DENV-infected patients showed an increase in the frequency of intermediate monocytes and a decrease in the classical monocytes when compared to healthy individuals. Although these differences did not correlate with disease severity, changes during the early phase of infection gradually returned to normal in the defervescence phase. Moreover, decreased frequency of classical monocytes was associated with a significant up-regulation of co-stimulatory molecules CD40, CD86 and ICOSL. Kinetics of these co-stimulatory molecule-expressing classical monocytes showed different patterns throughout the sampling times of acute DENV infection. Different distribution of monocyte subsets and their co-stimulatory molecules in the peripheral blood during acute infection might exacerbate immune responses like cytokine storms and ADE, and future studies on intracellular molecular pathways utilized by these monocyte linages are warranted.
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人类单核细胞中的MHC II类抗原表现途径通过子集有所不同，受细胞因子调节。
影响因子：
3.7
作者：
Lee J;Tam H;Adler L;Ilstad-Minnihan A;Macaubas C;Mellins ED
通讯作者：
Mellins ED
DOI：
10.1084/jem.146.1.218
发表时间：
1977-07-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Halstead SB;O'Rourke EJ;Allison AC
通讯作者：
Allison AC
影响因子：
5.4
作者：
Fink, Katja;Ng, Cedrig;Schul, Wouter
通讯作者：
Schul, Wouter
影响因子：
3.7
作者：
Arias, Julia;Valero, Nereida;Alvarez-Mon, Melchor
通讯作者：
Alvarez-Mon, Melchor
DOI：
10.1161/atvbaha.118.311022
发表时间：
2019-01-01
影响因子：
8.7
作者：
Hamers, Anouk A. J.;Dinh, Huy Q.;Hedrick, Catherine C.
通讯作者：
Hedrick, Catherine C.