A comprehensive expression analysis of the MIA gene family in malignancies: MIA gene family members are novel, useful markers of esophageal, lung, and cervical squamous cell carcinoma.
A comprehensive expression analysis of the MIA gene family in malignancies: MIA gene family members are novel, useful markers of esophageal, lung, and cervical squamous cell carcinoma.
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DOI：
10.18632/oncotarget.9082
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发表时间：
2016-05-24
期刊：
影响因子：
--
通讯作者：
Kuniyasu H
中科院分区：
文献类型：
--
作者：
Sasahira T;Kirita T;Nishiguchi Y;Kurihara M;Nakashima C;Bosserhoff AK;Kuniyasu H
黑色素瘤抑制活性（MIA）基因家族成员包括MIA、MIA 2和转运和高尔基体组织蛋白1（TANGO）。虽然MIA基因家族成员具有多种肿瘤相关功能，但其在恶性肿瘤中的详细作用仍不清楚。在这项研究中，477例肿瘤标本进行免疫组化筛选，以评估MIA基因家族的表达。为了验证分析，我们还研究了66例食管癌、145例肺癌和126例宫颈癌中MIA基因家族表达与临床病理因素之间的关系。MIA基因家族的表达频率在鳞状细胞癌中高于其他接受筛查的肿瘤类型。在验证分析中，MIA基因家族染色在与淋巴结和/或远处转移相关的食管癌和肺癌中频繁观察到。在宫颈癌中，MIA和TANGO免疫染色也与肿瘤进展和转移相关。此外，MIA 2在浸润性宫颈癌中的表达水平相对于宫颈上皮内瘤变中的表达水平上调3。无病生存分析显示，MIA、MIA 2或TANGO阳性患者的无病生存期明显短于阴性患者。我们的研究结果表明，MIA，MIA 2和TANGO可能是有用的诊断和治疗人类恶性肿瘤的分子靶点。
Melanoma inhibitory activity (MIA) gene family members include MIA, MIA2, and Transport and Golgi organization protein 1 (TANGO). Although MIA gene family members have several tumor-related functions, their detailed roles in malignancies remain poorly elucidated. In this study, 477 tumor specimens were subjected to immunohistochemical screening to evaluate MIA gene family expression. For a validation analysis, we also examined the association between MIA gene family expression and clinicopathological factors in 66 cases of esophageal cancer, 145 cases of lung cancer, and 126 cases of cervical cancer. The frequency of MIA gene family expression was higher among squamous cell carcinomas than among other tumor types subjected to screening. In the validation analysis, MIA gene family staining was observed frequently in esophageal and lung cancers associated with nodal and/or distant metastasis. In cervical cancers, MIA and TANGO immunostaining also correlated with tumor progression and metastasis. Furthermore, MIA2 expression levels in invasive cervical cancer were upregulated relative to those in cervical intraepithelial neoplasia 3. A disease-free survival analysis revealed that MIA-, MIA2, or TANGO-positive patients had a significantly shorter disease-free survival than did those patients who were negative. Our results suggest that MIA, MIA2, and TANGO may be useful diagnostic and therapeutic molecular targets in human malignancies.
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影响因子：
4.8
作者：
Bosserhoff, AK;Moser, M;Hellerbrand, C
通讯作者：
Hellerbrand, C
影响因子：
8.8
作者：
Kurihara M;Kirita T;Sasahira T;Ohmori H;Matsushima S;Yamamoto K;Bosserhoff AK;Kuniyasu H
通讯作者：
Kuniyasu H
影响因子：
1.2
作者：
Bosserhoff, AK;Moser, M;Buettner, R
通讯作者：
Buettner, R
影响因子：
24.5
作者：
Hellerbrand, C.;Amann, T.;Bosserhoff, A-K
通讯作者：
Bosserhoff, A-K
影响因子：
6.4
作者：
Jachimczak, P;Apfel, R;Bogdahn, U
通讯作者：
Bogdahn, U