Dosimetry of laser-accelerated carbon ions for cell irradiation at ultra-high dose rate
Dosimetry of laser-accelerated carbon ions for cell irradiation at ultra-high dose rate
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超高剂量率细胞照射激光加速碳离子剂量测定
DOI：
10.1088/1742-6596/1596/1/012038
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Milluzzo G
中科院分区：
文献类型：
--
作者：
Milluzzo G
目前，全球越来越多的中心使用带电粒子放射治疗。虽然质子是最广泛使用的离子种类，但碳离子由于其较高的线性能量转移（LET）和相对生物有效性（RBE）而在治疗抗辐射肿瘤方面显示出许多优势。传统碳治疗设施的复杂性和高成本刺激了对替代加速方法的研究，例如基于高功率激光与固体目标相互作用的过程。离子加速方面的最新发展使得卢瑟福阿普尔顿实验室 (RAL) 使用 GEMINI 激光系统首次研究了超高剂量率 (10 9-10 10 Gy/s) 下碳离子的生物效应。碳离子从超薄（10-20 nm）碳箔加速，并通过磁铁选择能量，允许以 10 MeV/u±8% 的平均碳能量照射细胞。采用了专门为这些低能离子设计的剂量测定方法，该方法基于未层压的 EBT3 放射变色薄膜的使用。将报告剂量测定安排的细节以及为预测细胞平面上的能量和剂量分布而进行的 Geant4 模拟。
Charged particle radiotherapy is currently used in an increasing number of centres worldwide. While protons are the most widely used ion species, carbon ions have shown many advantages for the treatment of radioresistant tumours, thanks to their higher Linear Energy Transfer (LET) and Relative Biological Effectiveness (RBE). The complexity and the high cost of conventional carbon therapy facilities has stimulated the investigation of alternative acceleration approaches such as the processes based on high-power laser interaction with solid targets. Recent developments in ion acceleration have allowed to investigate for the first time the biological effects of carbon ions at ultra-high dose-rate (10 9-10 10 Gy/s) using the GEMINI laser system at Rutherford Appleton Laboratory (RAL). Carbon ions were accelerated from ultrathin (10-20 nm) carbon foils and energy selected by a magnet allowing to irradiate the cells with an average carbon energy of 10 MeV/u±8%. A dosimetry approach specifically designed for these low-energy ions was employed, which was based on the use of unlaminated EBT3 Radiochromic films. The details of the dosimetry arrangement as well as the Geant4 simulation performed to predict the energy and the dose distribution at the cell plane will be reported.
将成像板探测器校准为 1-200 MeV 范围内的单能质子。
DOI：
10.1063/1.5009472
发表时间：
2017
期刊：
The Review of scientific instruments
影响因子：
--
作者：
N. Rabhi;D. Batani;G. Boutoux;J. Ducret;K. Jakubowska;I. Lantuéjoul;C. Nauraye;A. Patriarca;A. Saïd;A. Semsoum;L. Sérani;B. Thomas;B. Vauzour
通讯作者：
B. Vauzour
影响因子：
1.6
作者：
Doria, D.;Kakolee, K. F.;Borghesi, M.
通讯作者：
Borghesi, M.