Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases.
Regulatory Effect of Mesenchymal Stem Cells on T Cell Phenotypes in Autoimmune Diseases.
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间充质干细胞对自身免疫性疾病中T细胞表型的调节作用
DOI：
10.1155/2021/5583994
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发表时间：
2021
影响因子：
4.3
通讯作者：
Mao F
中科院分区：
文献类型：
--
作者：
Wei Z;Yuan J;Wang G;Ocansey DKW;Xu Z;Mao F
骨髓间充质干细胞（mesenchymal stem cells，MSCs）的研究始于骨髓来源的细胞具有修复组织的能力这一最早假设。此后，一些科学家记录了骨髓源性MSC（BM-MSC）在胚胎骨和软骨形成、成人骨折和组织修复以及治疗应用中的免疫调节活性等过程中的关键作用。除了BM-MSC之外，已经报道了几种来源的MSC具有组织修复和免疫调节能力，使其成为许多疾病的潜在治疗选择。因此，已经探索了MSC在包括自身免疫性病症在内的各种疾病中的治疗潜力。除了大多数自身免疫性疾病患者的T细胞亚群失衡外，它们还表现出复杂的疾病表现，疾病之间的重叠症状和难以治疗。MSC可以调节T细胞亚群，以恢复其免疫稳态，从而在自身免疫性疾病中解决疾病。本文综述了骨髓间充质干细胞通过调节T细胞表型在缓解自身免疫性疾病中的作用。
Research on mesenchymal stem cells (MSCs) starts from the earliest assumption that cells derived from the bone marrow have the ability to repair tissues. Several scientists have since documented the crucial role of bone marrow-derived MSCs (BM-MSCs) in processes such as embryonic bone and cartilage formation, adult fracture and tissue repair, and immunomodulatory activities in therapeutic applications. In addition to BM-MSCs, several sources of MSCs have been reported to possess tissue repair and immunoregulatory abilities, making them potential treatment options for many diseases. Therefore, the therapeutic potential of MSCs in various diseases including autoimmune conditions has been explored. In addition to an imbalance of T cell subsets in most patients with autoimmune diseases, they also exhibit complex disease manifestations, overlapping symptoms among diseases, and difficult treatment. MSCs can regulate T cell subsets to restore their immune homeostasis toward disease resolution in autoimmune conditions. This review summarizes the role of MSCs in relieving autoimmune diseases via the regulation of T cell phenotypes.
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影响因子：
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