The structural brain network topology of episodic memory.

The structural brain network topology of episodic memory.
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DOI:
10.1371/journal.pone.0270592
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发表时间:
2022
期刊:
影响因子:
3.7
通讯作者:
--
中科院分区:
综合性期刊3区
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--
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情景记忆是由大脑区域的分布式网络支持的,而这个复杂的区域网络并不是孤立地运作的。迄今为止,这一领域的神经科学研究通常集中在特定区域的激活水平或这些区域之间的成对连接上。然而,研究尚未调查结构大脑网络的复杂相互作用如何影响情景记忆能力。我们将图论方法应用于基于扩散的解剖网络,以检查支持有效情景记忆功能所需的内侧颞叶的结构结构。我们研究了在言语和非言语情景记忆测试中的表现与节点强度之间的关系,节点强度是指大脑区域在网络中的连接程度。研究结果映射到后内侧记忆系统,由海马旁皮层提供服务,并与先前使用不同方法的情景记忆研究结果重叠。这扩展了我们目前的理解,为已识别区域的重要性提供了独立的证据,并提出了这些区域支持情景记忆的特殊方式。
Episodic memory is supported by a distributed network of brain regions, and this complex network of regions does not operate in isolation. To date, neuroscience research in this area has typically focused on the activation levels in specific regions or pairwise connectivity between such regions. However, research has yet to investigate how the complex interactions of structural brain networks influence episodic memory abilities. We applied graph theory methods to diffusion-based anatomical networks in order to examine the structural architecture of the medial temporal lobe needed to support effective episodic memory functioning. We examined the relationship between performance on tests of verbal and non-verbal episodic memory with node strength, which indexes how well connected a brain region is in the network. Findings mapped onto the Posterior Medial memory system, subserved by the parahippocampal cortex and overlapped with findings of previous studies of episodic memory employing different methodologies. This expands our current understanding by providing independent evidence for the importance of identified regions and suggesting the particular manner in which these regions support episodic memory.
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