Association between ECE1 gene polymorphisms and risk of intracerebral haemorrhage.
Association between ECE1 gene polymorphisms and risk of intracerebral haemorrhage.
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ECE1基因多态性与脑出血风险的关联
DOI：
10.1177/0300060516635385
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Zeng Y;Ma M;Liu B;Xia J;Xu H;Liu Y;Du X;Hu Z;Yang Q;Zhang L
目的探讨内皮素转换酶-1 （ECE1）基因多态性是否通过影响血压与脑出血（ICH）易感性相关。本病例对照研究招募了来自中国南方汉族人群的脑出血患者和健康对照者。对ECE1基因多态性rs212528和rs213045进行基因分型。评估基因型与脑出血风险之间的关系。分析了这两种ECE1基因多态性对血压的影响。共有389例脑出血患者和404名健康对照者参加了研究。即使在调整了不同的混杂变量后，ECE1 rs212528和rs213045多态性与ICH之间也没有显著的相关性。在脑出血患者中，rs212528 AA基因型患者的收缩压明显低于AG/GG基因型患者。这些结果表明，尽管rs212528可能影响脑出血患者的血压，但ECE1 rs212528和rs213045多态性在脑出血遗传易感性中没有主要作用。
To determine whether endothelin converting enzyme-1 (ECE1) gene polymorphisms contribute to susceptibility to intracerebral haemorrhage (ICH) by influencing blood pressure. This case–control study enrolled patients with ICH and healthy control subjects from a Southern Han Chinese population. The ECE1 gene polymorphisms rs212528 and rs213045 were genotyped. The association between the genotypes and the risk of ICH was assessed. The effects of these two ECE1 gene polymorphisms on blood pressure were also analysed. A total of 389 patients with ICH and 404 healthy control subjects participated in the study. There was no significant association between the ECE1 rs212528 and rs213045 polymorphisms and ICH even after adjusting for different confounding variables. In patients with ICH, the systolic blood pressure of patients with the rs212528 AA genotype was significantly lower than that of patients with the AG/GG genotypes. These results indicated that the ECE1 rs212528 and rs213045 polymorphisms had no major role to play in the genetic susceptibility to ICH, although rs212528 might influence blood pressure in patients with ICH.
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影响因子：
4.1
作者：
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通讯作者：
Lee, KS
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3.1
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3.5
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通讯作者：
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影响因子：
3.2
作者：
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通讯作者：
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64.5
作者：
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通讯作者：
YANAGISAWA, M