Afferent inputs to mid- and lower-lumbar spinal segments are necessary for stepping in spinal cats.
Afferent inputs to mid- and lower-lumbar spinal segments are necessary for stepping in spinal cats.
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DOI：
10.1111/j.1749-6632.2010.05540.x
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发表时间：
2010-06
影响因子：
5.2
通讯作者：
Mushahwar VK
中科院分区：
文献类型：
--
作者：
Norton JA;Mushahwar VK
众所周知，传入输入可以调节运动中枢模式发生器的活动，但它们在运动模式生成中的作用仍然不确定。本研究旨在探讨传入输入对于成年猫产生双侧协调后肢迈步的重要性。完成脊柱横断后，训练动物踩在跑步机的移动带上，直到建立后肢熟练的负重行走。然后对到达腰骶部增大的各个节段的根进行选择性背根切断术，并重新评估后肢迈步能力。根据腰骶段传入神经缺失的情况，迈步要么被废除，要么不受影响。中腰椎 (L3/L4) 或下腰椎 (L5-S1) 节段的传入神经阻滞导致运动丧失。使用血清素或肾上腺素激动剂无法恢复这些动物的运动能力。 L3、L6 或 S1 的传入神经阻滞对运动有轻微影响。这表明与髋部位置（中腰）和肢体负荷（下腰）相关的关键传入输入在脊髓损伤后运动模式的生成中发挥重要作用。
Afferent inputs are known to modulate the activity of locomotor central pattern generators, but their role in the generation of locomotor patterns remains uncertain. This study sought to investigate the importance of afferent input for producing bilateral, coordinated hindlimb stepping in adult cats. Following complete spinal transection, animals were trained to step on the moving belt of a treadmill until proficient, weight-bearing stepping of the hindlimbs was established. Selective dorsal rhizotomies of roots reaching various segments of the lumbosacral enlargement were then conducted, and hindlimb stepping capacity was reassessed. Depending on the deafferented lumbosacral segments, stepping was either abolished or unaffected. Deafferentation of mid-lumbar (L3/L4) or lower-lumbar (L5-S1) segments abolished locomotion. Locomotor capacity in these animals could not be restored with the administration of serotonergic or adrenergic agonists. Deafferentation of L3, L6, or S1 had mild effects on locomotion. This suggested that critical afferent inputs pertaining to hip position (mid-lumbar) and limb loading (lower-lumbar) play an important role in the generation of locomotor patterns after spinal cord injury.
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影响因子：
2.5
作者：
Ekeberg, O;Pearson, K
通讯作者：
Pearson, K
DOI：
10.1111/j.1748-1716.1967.tb03636.x
发表时间：
1967-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
JANKOWSKA, E;JUKES, MGM;LUNDBERG, A
通讯作者：
LUNDBERG, A
影响因子：
2.5
作者：
Lam, T;Pearson, KG
通讯作者：
Pearson, KG
DOI：
10.1111/j.1748-1716.1967.tb03637.x
发表时间：
1967-01-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
JANKOWSKA, E;JUKES, MGM;LUNDBERG, A
通讯作者：
LUNDBERG, A
影响因子：
2.5
作者：
Hiebert, GW;Whelan, PJ;Pearson, KG
通讯作者：
Pearson, KG