Polo-box domain: a versatile mediator of polo-like kinase function.
Polo-box domain: a versatile mediator of polo-like kinase function.
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DOI：
10.1007/s00018-010-0279-9
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发表时间：
2010-06
影响因子：
8
通讯作者：
Lee, Kyung S.
中科院分区：
文献类型：
--
作者：
Park, Jung-Eun;Soung, Nak-Kyun;Johmura, Yoshikazu;Kang, Young H.;Liao, Chenzhong;Lee, Kyung H.;Park, Chi Hoon;Nicklaus, Marc C.;Lee, Kyung S.
Members of the polo subfamily of protein kinases have emerged as important regulators in diverse aspects of the cell cycle and cell proliferation. A large body of evidence suggests that a highly conserved polo-box domain (PBD) present in the C-terminal non-catalytic region of polo kinases play a pivotal role in the function of these enzymes. Recent advances in our comprehension of the mechanisms underlying mammalian polo-like kinase 1 (Plk1)-dependent protein-protein interactions revealed that the PBD serves as an essential molecular mediator that brings the kinase domain of Plk1 in proximity with its substrates mainly through phospho-dependent interactions with its target proteins. In this review, current understanding of the structure and functions of PBD, mode of PBD-dependent interactions and substrate phosphorylation, and other phospho-independent functions of PBD are discussed.
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