PDZ binding kinase (PBK) is a theranostic target for nasopharyngeal carcinoma: driving tumor growth via ROS signaling and correlating with patient survival.
PDZ binding kinase (PBK) is a theranostic target for nasopharyngeal carcinoma: driving tumor growth via ROS signaling and correlating with patient survival.
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PDZ 结合激酶 (PBK) 是鼻咽癌的治疗诊断靶标：通过 ROS 信号传导驱动肿瘤生长并与患者生存相关
DOI：
10.18632/oncotarget.8445
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发表时间：
2016-05-03
期刊：
影响因子：
--
通讯作者：
Qian CN
中科院分区：
文献类型：
--
作者：
Wang MY;Lin ZR;Cao Y;Zheng LS;Peng LX;Sun R;Meng DF;Xie P;Yang JP;Cao L;Xu L;Huang BJ;Qian CN
Nasopharyngeal carcinoma (NPC) is well known as one of the most common malignancies in southern China and Southeast Asia. However, the mechanisms underlying NPC progression remain poorly understood. Herein, through overlapping the differentially expressed genes from 3 microarray data sets with the human kinome, we identified PBK, a serine-threonine kinase, is highly upregulated and has not been intensively investigated in NPC. PBK was required for malignant phenotypes of NPC, as PBK depletion by RNAi and inhibition by specific inhibitor HI-TOPK-032 obviously reduced cell proliferation and xenograft tumor growth in mice. Moreover, we determined that targeting PBK could accelerate apoptosis by inducing ROS that activates JNK/p38 signaling pathway. In NPC patients, elevated PBK expression in primary tumor positively correlated to clinical severity such as advanced T stage, high death risk and disease progression, and it could serve as an unfavorable independent indicator of overall survival and disease-free survival. Altogether, our results indicate that PBK is a novel significant regulator of NPC progression and a potential therapeutic target for NPC patients.
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影响因子：
11.2
作者：
Kim, Dong Joon;Li, Yan;Dong, Zigang
通讯作者：
Dong, Zigang
影响因子：
3.8
作者：
Dodd, Athena T.;Morelli, Joseph;Crane, Lori A.
通讯作者：
Crane, Lori A.
尿激酶型纤溶酶原激活剂受体信号传导在鼻咽癌细胞生长和转移中至关重要
影响因子：
4.3
作者：
Bao, Ying-Na;Cao, Xue;Qian, Chao-Nan
通讯作者：
Qian, Chao-Nan
影响因子：
8
作者：
Hu, F.;Gartenhaus, R. B.;Rapoport, A. P.
通讯作者：
Rapoport, A. P.
DOI：
10.1515/dmdi-2013-0062
发表时间：
2014
期刊：
Drug metabolism and drug interactions
影响因子：
--
作者：
Khurana V;Minocha M;Pal D;Mitra AK
通讯作者：
Mitra AK