Disordered follicle development.
Disordered follicle development.
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DOI：
10.1016/j.mce.2012.07.011
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发表时间：
2013-07-05
影响因子：
4.1
通讯作者：
Cook-Andersen H
中科院分区：
文献类型：
--
作者：
Chang RJ;Cook-Andersen H
卵巢卵泡形态和功能的改变在PCOS患者中已有很好的记录。这些包括腔前卵泡数量增加，卵泡生长失败超过中腔期，颗粒细胞退化和卵泡膜细胞增生的证据。功能异常包括反常的颗粒细胞对FSH的高反应性，这在临床上与排卵诱导期间的卵巢过度刺激有关。此外，有可能是一个主要的卵泡膜细胞缺陷，占大多数的雄激素过量生产在这种疾病。卵泡功能改变的确切机制尚不完全清楚。然而，有几个因素似乎影响卵泡发育的正常进展，以及损害卵巢类固醇合成。这些因素包括卵巢内和卵巢外的影响，这些影响扭曲了正常的卵巢生长，破坏了卵泡细胞产生类固醇。
Alterations of ovarian follicle morphology and function have been well documented in women with PCOS. These include increased numbers of growing preantral follicles, failure of follicle growth beyond the mid-antral stage, evidence of granulosa call degeneration, and theca cell hyperplasia. Functional abnormalities include paradoxical granulosa cell hyperresponsiveness to FSH which is clinically linked to ovarian hyperstimulation during ovulation induction. In addition, there is likely a primary theca cell defect that accounts for the majority of excess androgen production in this disorder. The precise mechanisms responsible for altered follicle function are not completely clear. However, several factors appear to influence normal advancement of follicle development as well as impair ovarian steroidogenesis. These include intra- as well as extraovarian influences that distort normal ovarian growth and disrupt steroid production by follicle cells.
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影响因子：
4.8
作者：
CARA, JF;ROSENFIELD, RL
通讯作者：
ROSENFIELD, RL
影响因子：
4.8
作者：
ERICKSON, GF;HSUEH, AJW
通讯作者：
HSUEH, AJW
影响因子：
5.8
作者：
ERICKSON, GF;MAGOFFIN, DA;CHANG, RJ
通讯作者：
CHANG, RJ
影响因子：
2.1
作者：
DANIEL, SAJ;ARMSTRONG, DT
通讯作者：
ARMSTRONG, DT
影响因子：
5.8
作者：
BARBIERI, RL;MAKRIS, A;RYAN, KJ
通讯作者：
RYAN, KJ