Nephroprotective mechanism(s) of pentoxifylline: reduction of erythrocyte-mediated vascular congestion and inhibition of nitric oxide release.
Nephroprotective mechanism(s) of pentoxifylline: reduction of erythrocyte-mediated vascular congestion and inhibition of nitric oxide release.
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己酮可可碱的肾保护机制：减少红细胞介导的血管充血并抑制一氧化氮的释放。
DOI：
10.1111/j.1600-0773.1996.tb00200.x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Wasan,KM
中科院分区：
文献类型：
--
作者：
Vadiei,K;Tucker,SD;Lopez-Berestein,G;Wasan,KM
The present study attempted to evaluate pentoxifylline's mechanism(s) of action in the prevention of acute renal failure by examining its vascular decongestant activity in a rat model for acute renal failure and inhibitory activity of nitric oxide release from activated macrophage‐like (RAW 264.7 cells) and murine mammary adenocarcinoma (EMT‐6 cells) cell lines. Radiolabeled chronium‐erythrocytes were injected intravenously into all rats. Following occlusion of the left kidney for 45 minutes, rats were treated with pentoxifylline or normal saline. The medulla of the left (ischaemic) kidney had significantly higher radioactive counts than the right (control kidney) following an intravenous dose of normal saline. The medulla to whole blood radioactivity ratio of the left kidney was significantly greater than for the right (control) kidney. Animals administered intravenous pentoxifylline (5 mg/kg) had significantly lower radioactive counts in the medulla of the left (ischaemic) kidney than animals administered intravenous normal saline. No differences in radioactivity counts in the medulla of the left (ischaemic) kidney were observed when animals received intraperitoneal pentoxifylline (45 mg/kg) versus normal saline. In a second set of experiments the nitrite synthesis and percent cytotoxicity of pentoxifylline‐ and dexamethasone‐treated cells were determined. Pentoxifylline at concentrations of 4 mM and 8 mM significantly decreased nitrite synthesis in RAW 264.7 cells, and at pentoxifylline concentrations of 2 mM, 4 mM, and 8 mM in EMT‐6 cells compared to untreated cells. Dexamethasone at a concentration of 1 μM decreased nitrite synthesis in RAW 264.7 and EMT‐6 cells compared to untreated cells. Pentoxifylline at concentrations of 0.5 mM through 8 mM significantly decreased cytotoxicity in RAW 264.7 and EMT‐6 cells compared to untreated cells. Dexamethasone at a concentration of 1 μM decreased cytotoxicity in RAW 264.7 and EMT‐6 cells compared to untreated cells. These finding suggest that pentoxifylline's ability to prevent acute renal failure may be a consequence of reduced vascular congestion and inhibition of nitric oxide release from activated macrophages.
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DOI：
--
发表时间：
1987
期刊：
Federation proceedings
影响因子：
--
作者：
H. Movat;M. Cybulsky;I. Colditz;Chan Mk;C. Dinarello
通讯作者：
H. Movat;M. Cybulsky;I. Colditz;Chan Mk;C. Dinarello
用己酮可可碱预防环孢素引起的肾毒性。
影响因子：
3
作者：
L. J. Brunner;K. Vadiei;L. Iyer;D. Luke
通讯作者：
D. Luke
影响因子：
2.9
作者：
GREEN, LC;WAGNER, DA;TANNENBAUM, SR
通讯作者：
TANNENBAUM, SR
一氧化氮在内毒素休克中的保护和病理作用。
影响因子：
10.8
作者：
C. Wright;D. Rees;S. Moncada
通讯作者：
S. Moncada
用超氧化物歧化酶和蔗糖预防缺血性急性肾衰竭。
DOI：
10.1111/j.1748-1716.1987.tb08150.x
发表时间：
1987
期刊：
Acta physiologica Scandinavica
影响因子：
--
作者：
A. Bayati;O. Hellberg;Bo Odlind;Mats Wolgast
通讯作者：
Mats Wolgast