Effects of Omega 3 Fatty Acids on Main Dimensions of Psychopathology.
Effects of Omega 3 Fatty Acids on Main Dimensions of Psychopathology.
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DOI：
10.3390/ijms21176042
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发表时间：
2020-08-21
影响因子：
5.6
通讯作者：
Bellino S
中科院分区：
文献类型：
--
作者：
Bozzatello P;De Rosa ML;Rocca P;Bellino S
在过去的几十年里，人们研究了多不饱和脂肪酸对炎症、心血管和神经系统的作用，但其有益特性的机制仍然部分未知。这些药物似乎表达了它们对膜磷脂组成和渗透性以及第二信使级联的调节的作用。在精神病学中，研究了omega-3脂肪酸在几种精神疾病中的疗效和耐受性，包括重度抑郁症、双相情感障碍、人格障碍、发展为精神病的高危状况、注意力缺陷多动障碍和自闭症谱系障碍。这一领域的初步研究结果令人鼓舞，但一些相关问题需要解决。特别是，这些药物对主要症状维度的影响必须从跨诊断的角度进行研究。本系统性综述旨在检查有关omega-3脂肪酸对精神病症状，情感症状，冲动性和攻击性，有害行为和自杀风险的有效性的可用数据。
The usefulness of polyunsaturated fatty acids on inflammatory, cardiovascular, and the nervous system was studied in the last decades, but the mechanisms underlying their benefic properties are still partially unknown. These agents seem to express their action on the membrane phospholipid composition and permeability and modulation of second messenger cascades. In psychiatry, the efficacy and tolerability of omega-3 fatty acids were investigated in several psychiatric disorders, including major depression, bipolar disorder, personality disorders, high-risk conditions to develop psychosis, attention-deficit hyperactivity disorder, and autism spectrum disorders. Initial findings in this field are promising, and some relevant questions need to be addressed. In particular, the effects of these agents on the main symptom dimensions have to be investigated in a trans-diagnostic perspective. The present systematic review is aimed to examine the available data on the efficacy of omega-3 fatty acids on domains of psychotic symptoms, affective symptoms, impulsivity, and aggressiveness, and harmful behaviors, and suicide risk.
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影响因子：
10.3
作者：
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通讯作者：
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影响因子：
11.3
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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